Multiplex ligation-dependent probe amplification analysis is useful for detecting a copy number gain of the FGFR1 tyrosine kinase domain in dysembryoplastic neuroepithelial tumors

ConclusionsWith recent findings of less frequent or absentFGFR1-ITD in pilocytic astrocytomas or rosette-forming glioneuronal tumors, the analysis ofFGFR1 aberrations, especiallyFGFR1-ITD, was suggested to be helpful to discriminate DNTs from their histological mimics.

http://link.springer.com/10.1007/s11060-019-03138-7

Source: Journal of Neuro-Oncology - February 28, 2019 Category: Cancer & Oncology Source Type: research