Confirmation of Erector Spinae Plane Block Analgesia for 3 Distinct Scenarios: A Case Report

Analgesia for many open thoracic and abdominal procedures has traditionally been accomplished through neuraxial techniques or paravertebral blocks. Erector spinae plane (ESP) blocks purport effective analgesia over a similar anatomical distribution with a more favorable side effect profile and complication rate than epidurals. However, the extent of clinical applicability for ESP blocks has yet to be elucidated. In this case series, we demonstrate the efficacy of ESP blocks for 3 distinct etiologies of acute pain: planned perioperative analgesia, rescue postoperative analgesia, and traumatic pain.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports Source Type: research

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Conclusions: Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion. PMID: 31517304 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
Conclusions: A wide variety of analgesia protocols are used. The three most frequently used are i.v. administered opioids, i.m. administered opioids, and non-sedative oral analgesics. The variety of analgesia protocols is not desirable in the context of good clinical practice, and considering the risks of combining opioids and benzodiazepines. Monitoring of vital functions was only performed after administration of i.v. medication. A comparison of the pain scores could be a first step in finding the optimal method of analgesia, thereby forming the basis of guidelines for analgesia during oocyte retrieval. PMID: 31517299 [PubMed]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
In conclusion, miR-101 had neuropathic pain-attenuating activity through targeting mTOR.
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Authors: Segarra AB, Prieto I, Martinez-Canamero M, Ruiz-Sanz JI, Ruiz-Larrea MB, De Gasparo M, Banegas I, Zorad S, Ramirez-Sanchez M Abstract OBJECTIVE: Enkephalins are neuropeptides involved in functions such as pain modulation and/ or cognitive processes. It has been reported that dietary fat modifies enkephalins in the brain. Since enkephalins are hydrolyzed by enkephalinases, the study of the influence of dietary fats, differing in their degree of saturation, on brain fatty acids content and enkephalinase activity is important to understand its regulatory role on neuropeptides under different type of diets. ...
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
Publication date: Available online 14 September 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): James J. Miller, Adam J. Kanack, Nancy M. DahmsAbstractBackgroundFabry disease is caused by α-galactosidase A deficiency. Substrates of this lysosomal enzyme accumulate, resulting in cellular dysfunction. Patients experience neuropathic pain, kidney failure, heart disease, and strokes.Scope of reviewThe clinical picture and molecular features of Fabry disease are described, along with updates on disease mechanisms, animal models, and therapies.Major conclusionsHow the accumulation of α-ga...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Conclusion: Gabapentin as an adjunctive drug could be more effective in reducing the severity of GI symptoms in patients with dyspepsia, especially neurological symptoms (such as pain, reflux, and indigestion). PMID: 31516891 [PubMed]
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Sandeep Kumar, Monika Nehra, Deepak Kedia, Neeraj Dilbaghi, K. Tankeshwar, Ki-Hyun KimAbstractBioimplant engineering aims to mature biological alternatives to restore, retain, or modify damaged tissues and/or the functionality of organs. Remarkable advancements in modern material technology have helped the diversity of materials for orthopaedic implant application. As such, nanomaterials can simulate the surface properties of natural tissues, especially with respect to surface topography, surface chemistry, surface energy, and ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yawara Eguchi, Keigo Enomoto, Takashi Sato, Atsuya Watanabe, Takayuki Sakai, Masaki Norimoto, Masami Yoneyama, Yasuchika Aoki, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Miyako Suzuki, Kazuhide Inage, Yasuhiro Shiga, Naoya Hirosawa, Masahiro Inoue, Masao Koda, Takeo FuruyaAbstractThere is no imaging modality to quantitatively evaluate compressed cervical nerve roots in cervical radiculopathy. Here we sought to evaluate the usefulness of simultaneous apparent T2 mapping and neurogra...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Authors: Zhou NB, Wang KG, Fu ZJ Abstract The combination of morphine and ketamine is considered safe and efficacious in many patients. However, a considerable number of immunomodulatory effects have been reported to be produced by both morphine and ketamine. The aim of the present study was to assess the direct effect of morphine and a low dose of ketamine on the T cells of patients with refractory cancer pain in vitro. Venous blood was obtained from patients with refractory cancer pain and peripheral blood mononuclear cells were isolated using the Ficoll-Hypaque density gradient method. Anti-CD3 beads were used t...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In this study, the safety, efficacy, and advantages of Q-PTP and single-pulse laser mode of 1064-nm QSNY in the treatment of melasma were compared. Twelve healthy women were enrolled in this split-face study. Q-PTP and single-pulse laser mode of 1064-nm QSNY were applied to the treatment side and the control side, respectively. Physician's global assessment, patients' self-assessment and the modified melasma area and severity index (mMASI) scores were used to quantify pigmentation changes. Side effects were recorded. Mean mMASI scores were decreased significantly at the 4th and 12th-week follow-up visit compared to the bas...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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