Evaluation of tryptase after subcutaneous immunotherapy –associated systemic reactions

Tryptase is an objective marker of mast cell burden and degranulation that is often released in conjunction with other mediators during anaphylaxis, resulting in transient elevation.1,2 In addition to elevations in absolute total tryptase levels, a few alternate definitions of tryptase levels elevations have been proposed, including an increase of 135%,3 a peak (SD) peak serum tryptase level of more than 2 + 1.2 times the baseline tryptase level,4 and more recently a reaction to baseline ratio of greater than 2.99.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letter Source Type: research