T cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients

This study delineates the mitochondrial defects in DOCK2-deficient T cells contributing to the T cell lymphopenia characteristic of this primary immunodeficiency.

Source: Journal of Allergy and Clinical Immunology - February 28, 2019 Category: Allergy & Immunology Authors: Mohammed F. Alosaimi, Hiba Shendi, Abdallah Beano, Kelsey Stafstrom, Rabab El Hawary, Safa Meshaal, Nermeen Galal, Sung-Yun Pai, Aisha El-Marsafy, Raif S. Geha, Janet Chou Source Type: research