Automatic PET cervical tumor segmentation by combining deep learning and anatomic prior.

Automatic PET cervical tumor segmentation by combining deep learning and anatomic prior. Phys Med Biol. 2019 Feb 28;: Authors: Chen L, Shen C, Zhou Z, Maquilan G, Albuquerque K, Folkert MR, Wang J Abstract Cervical tumor segmentation on 3D <sup>18</sup>FDG PET images is a challenging task because of the proximity between cervix and bladder, both of which can uptake <sup>18</sup>FDG tracers. This problem makes traditional segmentation based on intensity variation methods ineffective and reduces overall accuracy. Based on anatomy knowledge, including "roundness" of the cervical tumor and relative positioning between the bladder and cervix, we propose a supervised machine learning method that integrates convolutional neural network (CNN) with this prior information to segment cervical tumors. First, we constructed a spatial information embedded CNN model (S-CNN) that maps the PET image to its corresponding label map, in which bladder, other normal tissue, and cervical tumor pixels are labeled as -1, 0, and 1, respectively. Then, we obtained the final segmentation from the output of the network by a prior information constrained (PIC) thresholding method. We evaluated the performance of the PIC-S-CNN method on PET images from 50 cervical cancer patients. The PIC-S-CNN method achieved a mean Dice similarity coefficient (DSC) of 0.84 while region-growing, Chan-Vese, graph-cut, fully convolutional neural networks (FCN) based FC...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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ConclusionSince technical difficulties with a limited number of hands, some complex surgery like radical hysterectomy has rarely been performed through LESS approach[1]. The dissection of vesicocevical and parametrial space are critical to radical hysterectomy, dissatisfied exposure during the procedure are the majority difficulties[2]. In the video, surgery for cervical cancer was performed successfully and also met the FIGO standards for radical hysterectomy (Type C). Our video demonstrated that the varied and flexible suspension played a significant role to provide a clear vision and sufficiently exposure, it was feasib...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
CONCLUSIONS: According to our analysis, NSRH surgery after NAC via balloon occluded arterial infusion brings beneficial results to patients with bulky IB2 to IIB cervical cancers. PMID: 31497250 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: Low expressing levels of miRNA-15a indicated poor OS, while miRNA-15a can be used as a prediction biomarker in different cancer types. PMID: 31061821 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
CONCLUSIONS: IGABT using Vienna II applicator allows for appropriate target coverage in tumors extending into DP/LPW at the time of BT. Clinical use is feasible and results in good local control, DFS and OS with moderate rate of acute and late ≥G3 toxicity. PMID: 31495516 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
This study, for the first time, aims to quantify the impact of modulation restriction on plan quality indices in inverse optimization for cervix high-dose-rate (HDR) brachytherapy using the BEBIG SagiPlan treatment planning system. Material and methods: Ten cervical cancer patient plans were optimized for treatment with a BEBIG SagiNova 60Co HDR afterloader using the min/max inverse planning method, with dwell time homogeneity error weight (DTHEW) parameter values of 0 to 10. Dwell time homogeneity and gradients as well as various plan quality indices were analyzed. Results: For DTHEW = 0, min/max-based optimizatio...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusion: MN scoring on the epithelial cells of buccal mucosa can be used as a biomarker in screening procedures for HIV patients.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
Abstract Adaptive radiotherapy (ART) is a complexe image-guided radiotherapy modality that comprises multiple planning to account for anatomical variations occurring during irradiation. Schematically, two strategies of RTA can be distinguished and combined according to tumor locations. One or more replanning can be proposed to correct systematic variations such as tumor shrinkage. A library of treatment plans with day-to-day plan selection from cone-beam CT imaging can also be proposed to correct random variations such as uterine motion or bladder/rectum volume changes. Because of strong anatomical variations occu...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
AbstractIntroductionSurgery by open radical hysterectomy for cervical cancer is associated with sexual dysfunction as well as lymphedema and bladder problems. Our aim was to assess the impact of robot ‐assisted laparoscopic radical hysterectomy (RRH) with pelvic lymphadenectomy for early‐stage cervical cancer on sexual, bowel, bladder, and lymphatic function and to measure ovarian function after RRH.Material and methodsTwenty ‐six women with early‐stage cervical cancer during 2011‐2013 were investigated before and 1 year after RRH using a validated questionnaire measuring psychological well‐being and sexua...
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
This article summarizes the recent advances in research on the multifarious pharmacological effects of A. camphorata. The mushroom exhibits anticancer activity toward a large variety of cancers including breast, cervical, ovarian, prostate, bladder, colorectal, pancreatic, liver, and lung cancers; melanoma; leukemia; lymphoma; neuroblastoma; and glioblastoma. Other activities encompass antiinflammatory, antiatopic dermatitis, anticachexia, immunoregulatory, antiobesity, antidiabetic, antihyperlipidemic, antiatherosclerotic, antihypertensive, antiplatelet, antioxidative, antiphotodamaging, hepatoprotective, renoprotective, ...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
Apolipoprotein B mRNA editing enzyme catalytic subunit-like protein 3B (APOBEC3B or A3B), as other APOBEC3 members, is a single-stranded (ss)DNA cytosine deaminase with antiviral activity. A3B is also overexpressed in multiple tumor types, such as carcinomas of the bladder, cervix, lung, head/neck, and breast. A3B generates both dispersed and clustered C-to-T and C-to-G mutations in intrinsically preferred trinucleotide motifs (TCA/TCG/TCT). A3B-catalyzed mutations are likely to promote tumor evolution and cancer progression and, as such, are associated with poor clinical outcomes. However, little is known about cellular p...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
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