A 50-Year-Long Study of Waldenstr öm Macroglobulinemia

Waldenstr öm macroglobulinemia (WM) is a rare low-grade lymphoma in which lymphoplasmacytic cells infiltrate the bone marrow and produce monoclonal IgM protein.1 It has a well-defined immunophenotype, although exclusion of other low-grade lymphoproliferative disorders is required to confirm diagnosis.2 The c linical features of WM include a constellation of signs and symptoms related to infiltration of the bone marrow or other organs by the clonal cells, the production of the monoclonal immunoglobulin M (IgM) and its unique physicochemical and immunologic properties, as well as the production of cytokin es that may cause various symptoms and complications.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Commentary Source Type: research