Autoinflammatory/autoimmunity syndrome induced by adjuvants (Shoenfeld's syndrome) in patients after a polypropylene mesh implantation

In conclusion, 40 patients developed symptoms of a systemic illness after a mesh operation. All patients fulfilled the diagnostic criteria for ASIA. One quarter of the patients had an immunodeficiency, whereas in approximately half of the patients, an autoimmune disease developed. We postulate that PP mesh implants may increase the risk of developing (auto)immune diseases by acting as an adjuvant.
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research

Related Links:

CONCLUSIONS: These findings support the use of patient experiences and feedback to aide product development. In addition, post-9/11 veterans support the use of eScreening to assist health screening. However, evaluating the eScreening program in more diverse veteran groups and Veterans Affairs settings is needed to improve the generalizability of these findings to the larger veteran population. PMID: 32060553 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Teixeira JC, Jackson PJ Abstract Distinguishing between central and peripheral causes of vertigo can be challenging not only in an acute setting but also in chronic settings. A thorough review of systems and physical exam can assist providers in differentiating central versus peripheral etiologies and the need for urgent imaging. In this case, a 47-year-old man presented with vertigo, right-sided hearing loss, right-sided headache, and right-sided facial pain that began 4 weeks before while the patient was on a cruise ship. His physical exam findings were notable for anisocoria with right pupil 3.5 an...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Publication date: Available online 15 February 2020Source: Toxicology ReportsAuthor(s): Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. SeeffABSTRACTAs part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Life after opioids: 'We have not served our patients well' More than 3 million Australians are living with chronic pain, and the medical system is struggling to help them as it turns away from its reliance on opioids www.theguardian.com “You may have a patient that has been on a stable dose of opioids for 10 years, and then you start de-prescribing. We are now exposing them to new risks for opioid overdose, for suicidality, for actual suicide, for withdrawal symptoms, for increased pain.” People living in chronic pain are a hi...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
ConclusionOperative repair of stomal prolapse, regardless of approach, is associated with high recurrence rates. No identifiable factors were associated with recurrence.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Authors: Chelvanambi M, Weinstein AM, Storkus WJ Abstract The ability of the immune system to prevent or control the growth of tumor cells is critically dependent on inflammatory processes that lead to the activation, expansion, and recruitment of antitumor effector cells into the tumor microenvironment (TME). These processes are orchestrated by soluble cytokines produced in tissues that alarm local immune surveillance cells (such as dendritic cells, DCs) to mobilize protective antitumor immune populations (B cells, T cells). The interleukin (IL)-36 family of pro-inflammatory cytokines plays an important role ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
AbstractThis guideline aims to describe the complement system and the functions of the constituent pathways, with  particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical, alternative and lectin pathways, which converge with the cleavage of central C3. Complement deficiencies account for ~5% of PIDs. The clinical consequences of inherited defects in the complement system...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
AbstractAerophagia is a functional gastrointestinal disorder characterized by excessive swallowing of air associated with abdominal distension and pain, flatulence, belching, nausea, and vomiting. The purpose of the current study was to evaluate the effectiveness of an antecedent-based behavioral intervention on aerophagia with an adolescent female diagnosed with Lennox-Gastaut syndrome (LGS), severe intellectual disability, and herpes simplex virus infection of the central nervous system with chronic static encephalopathy. Results from a functional analysis and multiple-component aerophagia assessment suggested that aerop...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
Soares Albuquerque Indiara Penido Tayrine Araujo Santos Ana Paula Dinis Ano Bom Andrea Marques Vieira da Silva Camilla Bayma Fernandes Carlos Eduardo Calzavara Erna Geessien Kroon Olindo Assis Martins-Filho Andréa Teixeira-Carvalho Betânia Paiva Drumond One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver ...
Source: Viruses - Category: Virology Authors: Tags: Case Report Source Type: research
Publication date: Available online 15 February 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Brande Brown, Kathleen Long, Levon Agdere, Jolanta Kulpa, Sara Zarzoso-Fernandez, Deepak Choudhary, Revathy SundarumAbstractBackgroundWhile there is a known association between low vitamin D levels and increased chronic pain in patients with Sickle Cell Disease (SCD), there are no reported studies evaluating the relationship of vitamin D levels and hospitalization outcomes in this population. The aim of this study was to assess this relationship with hospitalization outcomes defined as the number of emergency room (ER)...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
More News: Allergy & Immunology | Autoimmune Disease | Chronic Fatigue Syndrome | Chronic Pain | Gastroschisis Repair | Hernia Mesh Repair | Hernia Repair | Irritable Bowel Syndrome | Pain | Rheumatology | Study | Women