Implants in patients with oral manifestations of autoimmune or muco-cutaneous diseases - A systematic review.
CONCLUSIONS: Guidelines regarding implant treatment of patients with oLp, Pe, EB, SjS, sLE or sSc do not exist nor are contraindicating conditions defined. Implant survival rates of patients affected are comparable to those of healthy patients. For implant-prosthetic rehabilitation of patients with Pe and sLE no conclusions can be drawn due to lack of sufficient clinical data. Implant-prosthetic treatment guidelines regarding healthy patients should be strictly followed, but frequent recall is recommended in patients affected with oLp, SjS, EB, SSc, Pe or sLE. PMID: 30818315 [PubMed - in process]
Authors: Tomczak H, Rogacki M, Wrońska M, Malińska N, Jenerowicz D, Czarnecka-Operacz M, Adamski Z PMID: 32467694 [PubMed]
Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis. PMID: 32467679 [PubMed]
In conclusion, the results from the present study suggested that miR‑29a may affect IgG antibody secretion in B cells by regulating CRKL, thereby contributing to the development and progression of SLE, which offers a novel candidate target for treatment. PMID: 32467986 [PubMed - as supplied by publisher]
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Publication date: Available online 29 May 2020Source: The Egyptian RheumatologistAuthor(s): Diana Nagy, Noha H. Shaheen, Heba M. Selim, Mai M. Sherif, Salma M. Saed, Hala R. Youssef, Omneya Osman, Taghrid Gaafar
Abstract In both mouse models and clinical patients with lupus, autophagy levels were significantly elevated and correlated with disease activity. Furthermore, autophagy can promote the survival of B and T cells, plasma cell differentiation, and antibody production. These results suggest that autophagy may promote the progression of lupus by regulating the survival of autoreactive immune cells. Therefore, we aimed at studying whether suppressing autophagy can modulate lupus progression in vivo. First, we found that the autophagy levels in splenocytes and lymphocytes of peripheral blood (PB) were elevated and posit...
Patients who rely on chloroquine and other medications fear they won ’t be able to get needed refills because of high demand.
Publication date: Available online 29 May 2020Source: International Journal of Nursing SciencesAuthor(s): Zheng HuangFu
Publication date: Available online 29 May 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Gardellini Angelo, Francesca Guidotti, Zancanella Michelle, Saccà Vittoria, Maddalena Feltri, Luciana Ambrosiani, Turrini Mauro