Major genetic study confirms that many genes contribute to risk for Tourette's syndrome

(Massachusetts General Hospital) A meta-analysis of multiple studies into the genetic background of Tourette's syndrome (TS) -- a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics -- finds that variants in hundreds of genes, working in combination, contribute to the development of the syndrome and suggests that Tourette's is part of a continuous spectrum of tic disorders, ranging from mild, sometimes transient tics to severe cases that can include psychiatric symptoms.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conditions:   Tourette Syndrome;   Tic Disorders;   Tics Intervention:   Behavioral: Distress Tolerance Skills Training Sponsors:   Johns Hopkins University;   Tourette Association of America Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Patients with TS display deficits of white matter microstructure in the CC and right ILF known to be important for interhemispheric connections as well as long association fiber bundles within one hemisphere. Because the results reported in the primary literature were highly variable, future investigations with large samples would be required to support the identified white matter changes in TS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
To determine the long-term durability of behavior therapy for tics among youth with Tourette ’s disorder and persistent (chronic) motor or vocal tic disorders.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New Research Source Type: research
This report presents a  case of TS reemergence against the background of immunological reaction or PANDAS with a late adolescent onset.
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research
Motor tics in patients with Tourette's syndrome can increase the risk for cervical spine disorders and related neurological conditions, new research suggests.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
A new compound containing THC and palmitoylethanolamide shows promise for reducing tics in adults with severe Tourette's syndrome in a small phase 2 trial.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Tourette syndrome is a childhood-onset neurodevelopmental disorder characterized by motor and vocal tics. On the neural level, tics are thought to be related to the disturbances of the cortico-basal ganglia-thalamo-cortical loops, which also play an important role in procedural learning. Several studies have investigated the acquisition of procedural information and the access to established procedural information in TS. Based on these, the notion of procedural hyperfunctioning, i.e., enhanced procedural learning, has been proposed. However, one neglected area is the retention of acquired procedural information, especially...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
J Diet Suppl. 2021 Aug 11:1-16. doi: 10.1080/19390211.2021.1958120. Online ahead of print.ABSTRACTVery little is known about the use of nutritional supplements in children with Tourette syndrome. The current study aimed to address the frequency of nutritional supplements and the use of special diets in children with Tourette syndrome and typically developing children. Additional data also sought to address the motivations behind using them, their cost and perceived benefits. A total of 76 responses from an anonymous online survey (Tourette syndrome = 42; typically developing = 34) were completed and analyzed. Fifty-six per...
Source: Journal of Dietary Supplements - Category: Nutrition Authors: Source Type: research
AbstractThe formation of a new umbrella organisation called Tics and Tourette Across the Globe (TTAG) representing Tic and Tourette Syndrome (TS) patient associations around the world has led to a clearer voice for patients with Tourette Syndrome (TS). An opportunity has been created for this group to bridge research, clinical work and shared decision-making between researchers, clinicians and patients across Europe, with the result of improving the treatment and management of TS. A survey was sent out to capture the patients ’ perspective on research and treatment, and 2269 participants responded. 71% of participant...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
This study explored the role of self-esteem in mediating the relationship between psychosocial stress and social adjustment among adolescents with Tourette syndrome, and the role of comorbidities in moderating the relationship between self-esteem and social adjustment.
Source: Journal of Pediatric Nursing - Category: Nursing Authors: Source Type: research
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