Cellular therapies for the endometrium: an update

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Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Commentary Source Type: research

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Abstract Endometrial dysfunction is a widespread problem that can result in both infertility and pregnancy loss. Perhaps the most extreme variant of endometrial dysfunction is failure to generate sufficient endometrial tissue, resulting in a thin endometrium incapable of supporting embryo implantation. In Asherman's syndrome this is due to destruction of the endometrium, typically after trauma, with subsequent scarring and fibrosis. The etiology of endometrial atrophy in the absence of Asherman's syndrome is generally unknown. PMID: 31925867 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Authors: Konci R, Caminsky N, Tulandi T, Dahan MH Abstract Intrauterine adhesions (IUAs) are a result of trauma to the basalis layer of the endometrium and may lead to clinical sequelae such as miscarriage, infertility, and menstrual irregularities. Hysteroscopy is recognized as the gold standard in diagnosis and management, although the optimal treatment after surgical intervention remains unclear. This review aimed to provide an update on the treatment options available after hysteroscopic adhesiolysis and to facilitate clinical management of patients with IUAs. To avoid duplicating previous work, the review focu...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
This study aimed to assess the feasibility and efficacy of office hysteroscopy to diagnose and treat the specific uterine pathologies frequently diagnosed and thought to be associated with female infertility.Material and methods: Using office hysteroscopy, we examined the uterine cavity in women with primary or secondary infertility and evaluated the reproductive outcomes of those affected by one or more pathologies, including cervico-isthmic adhesions, intrauterine polyps and intrauterine adhesions. Additional patient characteristics considered were age and parity, uterine pathology, pain during hysteroscopy, and outcomes...
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Publication date: Available online 16 November 2019Source: Life SciencesAuthor(s): Yalda Jahanbani, Soudabe Davaran, Maryam Ghahremani-Nasab, Leili Aghebati-Maleki, Mehdi YousefiAbstractTissue engineering and the use of scaffolds have shown high therapeutic potentialities about male and female infertility. Nowadays, many couples are suffering from infertility problems. There are different causes for infertility including chemotherapy (for male and female), uterine injuries, and intrauterine adhesions. Extra-cellular matrix in tissue engineering provides a supportive medium for blood or lymphatic vessels making it a suitabl...
Source: Life Sciences - Category: Biology Source Type: research
This study aims to assess whether increasing time intervals between hysteroscopy for IUAs and ET affects pregnancy outcomes in the ideal study group of those undergoing euploid frozen ET.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Open Communications 3: Hysteroscopy (11:00 AM — 12:45 PM) 11:21 AM Source Type: research
This study aimed to investigate the clinical factors affecting pregnancy rates following the surgical removal of intrauterine adhesions (IUAs) and subsequent in vitro fertilization and embryo transfer (IVF-ET). We retrospectively evaluated case data from patients who had undergone hysteroscopic surgery to remove varying degrees of IUAs and who had subsequently received assisted reproductive treatments with IVF-ET (in all 140 cycles) at our hospital between January, 2011 and January, 2015. The patient data were divided into either the pregnancy or non-pregnancy groups based on the pregnancy outcomes, and a number of clinico...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
The purpose of this video is to describe a novel uterine closure technique to prevent intrauterine adhesions after myomectomy. This is an important topic in the field as intrauterine adhesions can result in infertility, recurrent pregnancy loss, and future pregnancy complications, such as morbidly adherent placenta.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Video Session 3 Source Type: research
Tissue regeneration disorder after endometrial injury is an important cause of intrauterine adhesions, amenorrhea, and infertility in women. Both bone marrow mesenchymal stem cell (BMSC) transplantation and el...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
This study aimed to assess if the fecundity of women after surgical correction of the uterine septum is associated with septum size. A retrospective, single-center, cohort study was conducted in Peking Union Medical College Hospital using patients aged between 21 and 37 years. Hysteroscopic metroplasty was performed on 121 patients with a uterine septum. The septum size was assessed by ultrasonography and hysteroscopy. The subjects were divided into 3 groups: Group A consisted of 35 women with complete uterine septum (mean ± standard deviation (SD) age 28.29 ± 3.53; group B consisted of 48 women with ute...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Publication date: Available online 30 March 2019Source: Genes &DiseasesAuthor(s): Changjiang Li, Aiqi Cai, Congcong Sun, Yanhua Mao, Benyuan Wu, Yingfeng Zhang, Yuhan Wang, Shanbi Zhou, Jia WangAbstractTranscervical resection of adhesion (TCRA) is the standard treatment for the intrauterine adhesions, but the recurrence of adhesions is a tough problem for the gynecologist. In addition, the therapeutic strategy after TCRA about prevention of recurrence remains controversial especially for the patients with moderate to severe intrauterine adhesions (IUAs). Hence, we designed this study to explore the safety and efficacy ...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
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