Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R21 Clinical Trial Optional)

Funding Opportunity PA-19-201 from the NIH Guide for Grants and Contracts. The purpose of this FOAs are to encourage mechanistic research to investigate the impact of sleep disturbances on chronic pain. The mechanisms and processes underlying the contribution of sleep disturbances to chronic pain development and maintenance may be very broad. This FOA encourages interdisciplinary collaborations by experts from multiple fieldsneuroscientists, psychologists,endocrinologists, immunologists, geneticists, pharmacologists, chemists, physicists, behavioral scientists, clinicians, caregivers, and others in relevant fields of inquiry.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

Related Links:

This study is a meta-analysis — a study which includes many studies that are deemed similar enough to lump together, in order to increase the numerical power of the study and, ideally, the strength of the conclusions. The authors included studies that go all the way back to the mid-1990s — a time when cannabis was illegal in the US, different in potency, and when there was no choice or control over strains or cannabinoid compositions, as there is now. One of the studies in the meta-analysis included “cannabis dependent inpatients” in a German psychiatric hospital in which 118 patients were being det...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Marijuana Mental Health Source Type: blogs
Spinocerebellar ataxia type 10 (SCA10), one of the autosomal dominant ataxias, is characterized by slowly progressive gait ataxia, dysarthria, nystagmus, epilepsy as well as non-motor symptoms [1]. The latter include dysautonomia, cognitive deficits, chronic pain, psychiatric comorbidities and sleep disorders [ [1,2]]. SCA10 is caused by expansion of ATTCT pentanucleotide repeats in the ATXN10 gene – which codes for ataxin 10 [ [1–3]]. Recent experimental data suggested a possible relationship between SCA10 and development of cancer [4].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery. Older adults are having more surgical procedures As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
This review identified prospective cohort studies in the general population, which showed incidence (23 papers) and risk factors (37 papers) for fibromyalgia and chronic widespread pain. Median incidence of physician diagnosed fibromyalgia in the general population was 4.3 per 1000 person-years (range = 0.33-18.8) but 14.0 (1.2-32.7) if medical illness was present. Median incidence of chronic widespread pain was 12.5 per 1000 person-years (7.2-81.6) but 67 per 1000 person years (14.8-124) for those with pre-existing pain. Risk factors included various childhood difficulties, female sex (except with pre-existing medical dis...
Source: Pain - Category: Anesthesiology Tags: Comprehensive Review Source Type: research
This study examined potential benefits and harms associated with prescription opioid dose escalation. Participants from 2 institutions were enrolled in a 2-year prospective cohort study. All participants (n = 517) had a musculoskeletal pain diagnosis and were receiving a stable dose of long-term opioid therapy at baseline. Participants completed self-report measures of pain, disability, depression, and potential adverse effects at baseline and every 6 months for 2 years. We reviewed electronic health record data weekly to identify episodes of prescription opioid dose escalation; participants who had increases in their dose...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
CONCLUSIONS: Given that primary care is the dominant healthcare setting in which opioids are prescribed for chronic noncancer pain, programs are needed to assist primary care providers to meet the rigorous requirements of guideline concordant care. The current study examined participation factors in such a program and found that certain veterans were less likely to participate than others. Identifying such veterans at the outset, in combination with intentional recruitment efforts and individualized interventions, may promote entry into PC-POP. PMID: 32421838 [PubMed - in process]
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
Abstract CONTEXT: People with chronic ankle instability (CAI) display a lower regional and global health-related quality of life (HRQoL). Examinations of HRQoL outcomes associated with CAI have addressed younger adults, restricting our understanding of the long-term consequences of CAI. OBJECTIVE: To compare ankle regional and global HRQoL in middle-aged participants with and those without CAI. DESIGN: Cross-sectional study. SETTING: Laboratory. PATIENTS OR OTHER PARTICIPANTS: A total of 59 middle-aged volunteers, consisting of 18 with CAI (age = 50.2 ± 9.3 years), 17 who were ankle-spra...
Source: J Athl Train - Category: Sports Medicine Authors: Tags: J Athl Train Source Type: research
Abstract BACKGROUND: Chronic low back pain (CLBP) is a highly prevalent and disabling condition in the elderly, and yet it is undertreated and understudied in this patient population. Tapentadol is a central analgesic with an improved tolerability profile that may be particularly beneficial to the elderly CLBP. METHODS: We performed an observational retrospective study to comparatively assess the efficacy and tolerability of tapentadol in young and elderly patients with severe CLBP. Sixtyfive young patients (
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
Conclusions: These findings illustrate the interplay of psychosocial factors with chronic pain and sleep disturbance in a sample of low-income, predominantly African-American patients seeking care at a safety-net primary care clinic. The findings support integrated primary care as a way to target not only behavioral health issues but also the psychosocial factors entangled with physical health. PMID: 32399128 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Authors: Chmaj-Wierzchowska K, Rzymski P, Wojciechowska M, Parda I, Wilczak M Abstract Introduction: Endometriosis is a chronic disease that involves the development of endometrium outside the uterine cavity with pain component predominance. The aim of the study was to discuss the occurrence of health problems in patients with endometriomas and simple cysts and the effect of these problems on the daily functioning of the patients. Material and methods: The study included patients (n = 40) treated laparoscopically and/or by laparotomy due to lesions in the form of endometriomas or simple cysts. The control group...
Source: Archives of Medical Science - Category: Biomedical Science Tags: Arch Med Sci Source Type: research
More News: Allergy & Immunology | Chemistry | Chronic Pain | Clinical Trials | Contracts | Drugs & Pharmacology | Endocrinology | Funding | Genetics | Grants | Pain | Physics | Psychology | Research | Sleep Disorders | Sleep Medicine