Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R01 Clinical Trial Optional)

Funding Opportunity PA-19-200 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to encourage mechanistic research to investigate the impact of sleep disturbances on pain. The mechanisms and processes underlying the contribution of sleep and sleep disturbances to pain perception and the development and maintenance of chronic pain may be very broad. This FOA encourages interdisciplinary research collaborations by experts from multiple fieldsneuroscientists, psychologists, endocrinologists, immunologists, geneticists, pharmacologists, chemists, physicists, behavioral scientists, clinicians, caregivers, and others in relevant fields of inquiry.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Neuropsychopharmacology, Published online: 17 June 2019; doi:10.1038/s41386-019-0439-zSleep deficiency and chronic pain: potential underlying mechanisms and clinical implications
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
Abstract Background: Chronic migraine with medication overuse headache (CM-MOH) is the most common type of chronic migraine, and it increases risk of stroke and white matter lesions. These pathologic changes could induce cognitive decline. However, the alteration of cognitive function in CM-MOH patients is not established. Therefore, we took this study to reveal the cognitive performances in CM-MOH. Methods: This cross-sectional study was conducted between December 2015 and January 2017. Patients were divided into CM-MOH, CMwoMOH (chronic migraine without medication overuse), and MO (migraine without aura) gr...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Abstract Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Loud snoring ruins the lives of millions: the snorers’ as well as those who have to listen to it frequently. However, snoring isn’t just an annoyance. It can hint at a serious sleeping disorder: sleep apnea. Not only does the condition cause frustration in itself, but when looking at the comfort of it, its treatment could be compared to an attack of Aliens. How could digital health help patients who undergo sleep apnea treatment? Are there any ways to get rid of the Aliens? Almost 1 in 7 people have sleep apnea worldwide ‘Laugh and the world laughs with you, snore and you sleep alone’, that&rs...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Empowered Patients Health Sensors & Trackers adherence health app patient engagement sleep sleep apnea sleep apnea treatment sleep app technology therapy Source Type: blogs
I was looking back over the last 8 years since the first Wheat Belly book was released. It’s been 8 years of astounding, truly breathtaking stories of success over weight issues, health, and physical transformations that skeptics even today claim are impossible. It’s been a virtual avalanche of wonderful stories. Although I’ve seen all of them, often more than once, I could not help but be overcome with satisfaction and pride for the many, many spectacular photos and stories people have shared. So I thought it would be fun to re-post a small sample of some of these stories dating back from the start of th...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories grain-free Inflammation Source Type: blogs
Discussion: The current study highlights the importance of separating between-person and within-person differences when examining the relationship between physical activity and pain severity. Future studies should explore moderating factors that may help to explain random effects to better understand the types of individuals with positive or negative relationships between physical activity and pain severity.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Given the dearth of research on mutual maintenance in this area, this review and conceptual model could drive future research in this area. We argue for the development of tailored treatments for this unique population of youth to improve outcomes.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Discussion: Sleep disturbance was related significantly with chronic pain intensity and function by both direct and indirect pathways. These results are consistent with an emerging literature highlighting the potential significance of sleep disturbance in chronic pain patients, and provide further support for addressing sleep disturbance in the assessment and management of chronic pain.
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
ConclusionsThese findings indicated thatl-THP exerted analgesic effects by agonism D1R and antagonism D2R, and the antagonism of D2R mediated the hypnotic effect ofl-THP in PSNL mice.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Conditions:   Sleep Disturbance;   Chronic Low-back Pain Interventions:   Device: Trans cranial Direct Current Stimulation (tDCS);   Other: Craniosacral therapy (CST);   Other: tDCS+ CST Sponsor:   Maharishi Markendeswar University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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