A Pill, That ’s a Device, That Delivers a Drug!

Rani Therapeutics just achieved one of its most significant milestones since it was spun out of InCube Lab in 2012. The San Jose, CA-based company just finished conducting the first human study of its “robotic capsule” set to replace injections. Previously the device, which administers a pharmaceutical through a digestible pill, had been tested in more than 100 animal models. The human study was conducted at a Clinical Research Organization (CRO) in Texas under the Investigational Review Board (IRB) approval. There were two sub-groups, one cohort was fed and another fasted. Each subject swallowed a drug-free version of the RaniPill capsule. Rani Therapeutics said results revealed no sensation of the capsule inflating or deploying, and the successful passing of the remnants. The RaniPill capsule was well-tolerated by both male and female adult subjects of similar BMI with no adverse events. The study showed similar intestinal deployment times for both fasted and fed subjects, indicating that food does not impact the RaniPill capsule's performance. “We’re now preparing for our second in-human study, but this time with a drug,” Mir Imran, Rani's Chairman and CEO, told MD+DI. “That will happen within the next several months and we’re very excited about it. This will be another major milestone for the company and it will pave the way for us to start doing r...
Source: MDDI - Category: Medical Devices Authors: Tags: Implants Source Type: news

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Authors: Mou D, Kleiman EM, Nock MK Abstract Despite decades of suicide research, our ability to predict suicide has not changed. Why is this the case? We outline the unique challenges facing suicide research. Borrowing successful strategies from other medical fields, we propose specific research directions that aim to translate scientific findings into meaningful clinical impact. PMID: 32228741 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
CONCLUSIONS: The early phases of anxiety and depressive disorders in adolescence are marked by emotional symptoms that usually emerge in the context of negative life events. To contend with the negative effect of such events, a typical reappraisal strategy is to distance oneself and switch the focus of one's thinking. This brain-imaging study in adolescent girls prone to the development of emotional disorders has found functional changes in key neural networks that are involved in reappraisal and shown that this process is impaired. This is important because it provides an early indication of these common disorders and a p...
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/D0CP00645A, PaperKrishan Kumar, Navin Kumar Kumar Mogha, Ritu Yadav, Pannuru Venkatesu Synthesizing and understanding phase transition behavior of novel block copolymers is very crucial for fabricating next generation of smart materials with foreseeable applications. In this regard, we synthesized three random... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
We described the clients' profile and the services offered at the clinic to identify gaps in service provision and areas of improvement. A retrospective record review of data was carried out from the ARC collected from February 2009 to December 2017. We analyzed 2343 affidavits that were available. Out of 2343 records analysed, (2190) 93.5% were female and 6.5 % (153) were male. The median age was 23years (Q1=21; Q3= 29) for males and 19 years (Q1= 17; Q2=25) for females. Among the clients, 2164 (92.4%) received a baseline HIV test, and 263 females and 6 males tested positive. From 2010 to 2017, six clients' seroconversion...
Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
Publication date: Available online 2 April 2020Source: Urology Case ReportsAuthor(s): Yoshihiro Kawaguchi
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 1 April 2020Source: Preventive MedicineAuthor(s): R. Liam Sutherland, Jennifer Ormsbee, Joy Pader, Nauzer Forbes, Susanna Town, Robert J. Hilsden, Darren R. Brenner
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
The author has been a grief therapist in private practice for almost 40 years. The largest percentage of his clients have been suicide loss survivors, and in this article, the author reflects on the "lessons learned" about how grief therapy with survivors ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Commentary Source Type: news
This study sought to determine the prevalence and social determinants of depressive symptoms among university students in twelve countries. Particular focus was placed on th...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVES: Suicidal thoughts, for which college students are at risk, tend to be negatively associated with intentions to seek therapy, particularly among college-aged men. Emerging research suggests college students may seek psychological help online; ho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Suicide in adolescence is a worldwide issue, and it continues to present a serious problem in terms of its prevention. Among the various aspects of suicide, a very interesting area of research is represented by suicidal ideation. Recently, neuroimaging-bas...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
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