Podocyte-specific Expression of Cre Recombinase Promotes Glomerular Basement Membrane Thickening.

This study highlights the importance of including the appropriate controls for potential Cre-mediated toxicity in conditional gene targeting experiments. Indeed, omitting the Cre transgene control can result in critical errors during interpretation of experimental data. PMID: 30810063 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30810063?dopt=Abstract

Source: American Journal of Physiology. Renal Physiology - February 27, 2019 Category: Physiology Authors: Balkawade RS, Chen C, Crowley MR, Crossman DK, Clapp WL, Verlander JW, Marshall CB Tags: Am J Physiol Renal Physiol Source Type: research