Comparison of diabetic nephropathy between male and female eNOS-/- db/db mice.

Comparison of diabetic nephropathy between male and female eNOS-/- db/db mice. Am J Physiol Renal Physiol. 2019 Feb 27;: Authors: Ma Y, Li W, Yazdizadeh Shotorbani P, Dubansky BH, Huang L, Chaudhari S, Wu P, Wang LA, Ryou MG, Zhou Z, Ma R Abstract Sex is an important biological variable that impacts diverse physiological and pathological processes, including progression of diabetic nephropathy. Diabetic nephropathy is one of the most common complications of diabetes mellitus and is the leading cause of end stage renal disease. eNOS-/- db/db mouse is an appropriate and valuable model to study mechanisms in the development of diabetic nephropathy due to similarities of the features of diabetic kidney disease in this model to those in humans. The aim of the present study was to determine whether there was a sex difference in renal injury in eNOS-/- db/db mice. Both male and female eNOS-/- db/db mice showed hyperglycemia, obesity and renal hypertrophy. However, there was no significant difference in those variables between males and females. Furthermore, both male and female diabetic mice showed progressive albuminuria, significantly greater levels of serum creatinine and blood urea nitrogen compared to the same sex of wild type mice (non-diabetic controls). Although all the three variables in female eNOS-/- db/db mice had tendency to be greater than those in male eNOS-/- db/db mice, those sex differences were not statistically significa...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research