The influence of hERG1a and hERG1b isoforms on drug safety screening in iPSC-CMs

In this study we show that the activation kinetics in iPSC-CMs resemble hERG1b kinetics using Cs+ as a charge carrier. Not including hERG1b in drug safety testing might underestimate the actual role of hERG1b in repolarization and drug response, and might lead to inappropriate conclusions. We stress to focus more on including hERG1b in drug safety testing concerning IKr.
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research