The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice

ConclusionsOur findings demonstrate that deleting a single neurexin gene (Nrxn2 α) induces atypical structural connectivity within socially relevant brain regions. More generally, our combined within-subject DTI and CLARITY approach presents a new, more sensitive method of revealing hitherto undetectable differences in the autistic brain.
Source: Molecular Autism - Category: Molecular Biology Source Type: research