Kidney Safety Assessment: Current Practices in Drug Development

Summary: The kidney's role as a major route of metabolism and clearance of xenobiotics and its ability to concentrate the glomerular filtrate make it particularly vulnerable to drug-induced toxicity. Improving kidney safety is an active area of research and there is a need in early stages of drug development for strategies and model systems to reliably identify nephrotoxic compounds and sufficiently characterize mechanisms to support drug pipeline decision making. In later stages of drug development the value of sensitive translational biomarkers to monitor kidney toxicity across species in nonclinical and clinical settings is gaining realization.

Source: Seminars in Nephrology - February 28, 2019 Category: Urology & Nephrology Authors: Sean P. Troth, Frank Simutis, Gary S. Friedman, Susan Todd, Frank D. Sistare Source Type: research