Impact of Deficiencies in Branched-Chain Fatty Acids and Staphyloxanthin in Staphylococcus aureus.

This study was conducted with the hypothesis that the simultaneous lack of BCFAs and staphyloxanthin will have a far greater implication on environmental survival and virulence of S. aureus. Lack of a functional branched-chain α-keto acid dehydrogenase (BKD) enzyme because of a mutation in the lpdA gene led to a decrease in the production of BCFAs, membrane fluidity, slower growth, and poor in vivo survival of S. aureus. A mutation in the crtM gene eliminated the production of staphyloxanthin but it did not affect membrane BCFA levels, fluidity, growth, or in vivo survival. A crtM:lpdA double mutant showed much slower growth and attenuation compared to individual mutants. The results of this study suggest that simultaneous targeting of the BCFA and staphyloxanthin biosynthetic pathways can be a strategy to control S. aureus infections. PMID: 30805362 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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ConclusionsIn experienced centers, Ross procedure is a reliable alternative to prosthetic or homograft valve replacement in young adults suffering from active aortic valve endocarditis, with a low operative risk and good long-term results.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Pukai G, Duke T Abstract Background: Acute lower respiratory tract infections are the commonest cause of hospitalisation in young children and supportive care remains the cornerstone of management. A randomised open trial was undertaken at the Port Moresby General Hospital Children's Emergency Department (CED) to determine whether nebulised normal saline had beneficial effects.Methods: Children
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
Publication date: Available online 19 February 2020Source: Journal of the American College of RadiologyAuthor(s): Soheil Kooraki, Melina Hosseiny, Lee Myers, Ali GholamrezanezhadAbstractIn December 2019, a novel coronavirus pneumonia was emerged in Wuhan, China. Since then, this highly contagious coronavirus has been spreading worldwide with a rapid rise in the number of death tolls. The novel coronavirus infected pneumonia (NCIP) is characterized by fever, fatigue, dry cough and dyspnea. A variety of chest imaging features have been reported, similar to those found in other types of coronavirus syndromes. The purpose of t...
Source: Journal of the American College of Radiology - Category: Radiology Source Type: research
Ventilators are used by patients who lose lung function due to complications from a variety of diseases such as spinal cord injuries, COPD, stroke, pneumonia, and ALS. In addition to dealing with a debilitating situation, patients tend to be hooked t...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiology Critical Care Exclusive Medicine Pediatrics Rehab Source Type: blogs
ConclusionThere was an increase in the prevalence of neuroischemic DFU. The Enterobacteriaceae family replaced SA as the most prevalent pathogen in DFI, with an increase in the isolation of gram-negative microorganisms and mixed polymicrobial cultures. Chronic neuroischemic infected ulcers usually present distinct bacterial isolates; knowledge about the most common agents is warranted in order to better select empiric antibiotic therapy.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
CONCLUSION: Culture-negative peritonitis had superior outcomes compared to culture-positive peritonitis except for non-staphylococcal gram-positive peritonitis. PMID: 32063153 [PubMed - in process]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
(TEHRAN, Iran) — The new virus has killed two elderly Iranian citizens, Iran’s state-run IRNA news agency reported Wednesday. IRNA quoted Alireza Vahabzadeh, an adviser to the country’s health minister, as saying that both of the victims had been carrying the coronavirus and were located in Qom, about 140 kilometers (86 miles) south of the capital Tehran. No additional details were released. Earlier on Wednesday, Iranian authorities confirmed two cases of the new virus, the first in the country, according to the semi-official ISNA news agency. Officials later said the two patients had died. ISNA quoted an...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Iran onetime Source Type: news
Publication date: September 2020Source: Materials Today Communications, Volume 24Author(s): Chanon Talodthaisong, Wissuta Boonta, Saengrawee Thammawithan, Rina Patramanon, Nuntaporn Kamonsutthipaijit, James A. Hutchison, Sirinan KulchatAbstractBiomaterial-based hydrogels incorporating antibacterial agents may provide sustainable solutions to biomedical device failures and the prevention of infections. Herein we report guar gum hydrogels, cross-linked with borax and loaded with silver nanoparticles, that are injectable, exhibit rapid self-healing, and show antibacterial properties towards both gram-positive and gram-negativ...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: Available online 19 February 2020Source: Materials LettersAuthor(s): Yang Jiao, Qian Liu, Jihua ChenAbstractClinically, non-desired osseointegration and bacterial-associated infection are responsible for the failure of titanium (Ti)-based implantation in orthopedic field. Herein, bone morphogenetic protein 2 (BMP2) loaded TiO2 nanotubes (TNT) arrays were fabricated on Ti substrates. Next, bioactive multilayer films of MA-modified gelatin (GelMA) and N-Cl modification poly (N, N’-methylene bis(acrylamide)) (PMAA-Cl) were deposited onto the BMP2-loaded TNT substrates with layer-by-layer (LBL) self-ass...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: Available online 19 February 2020Source: Materials LettersAuthor(s): Jingxiang Zhang, Shengqian Zhu, Kunkun Song, Zhuoyue Wang, Zongpu Han, Keren Zhao, Zengjie Fan, Xi Zhou, Qiangqiang ZhangAbstractThree-dimensional (3D) graphene/nano-copper scaffolds (rGCSs) was fabricated using a one-step chemical deposition on 3D reduced graphene oxide architecture (rGOA). The nano-copper was conformably grown on the rGOA substrate with a uniform morphology. Due to combined effects between the graphene skeleton and the nano-copper, the rGCSs demonstrated excellent antibacterial properties in the colony counting experim...
Source: Materials Letters - Category: Materials Science Source Type: research
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