Negative pressure wound therapy promoted wound healing by suppressing inflammation via down-regulating MAPK-JNK signaling pathway in diabetic foot patients

Inflammation is a host protective response to tissue injury and infection. Upon recognition of a pathogen, resident macrophages initiate an early inflammation response that recruits immune system including neutrophils and monocytes to produce inflammatory cytokines, such as interleukin- β (IL-β) and tumor necrosis factor-α (TNF-α) [1,2]. This overwhelming “cytokine storm” can result in deregulation of tissue matrix metalloproteinases (MMPs), and limit the formation and maturation of granulation tissue [3].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research