Early-life adversity programs long-term cytokine and microglia expression within the HPA axis in female Japanese quail. [RESEARCH ARTICLE]

David J. Walker, Cedric Zimmer, Maria Larriva, Susan D. Healy, and Karen A. Spencer Stress exposure during pre and post-natal development can have persistent and often dysfunctional effects on several physiological systems, including immune function, affecting the ability to combat infection. The neuro-immune response is inextricably linked to the action of the Hypothalamic Pituitary Adrenal (HPA) axis. Cytokines released from neuro-immune cells, including microglia, activate the HPA axis while glucocorticoids in turn regulate cytokine release from microglia. Because of the close links between these two physiological systems, coupled with potential for persistent changes to HPA axis activity following developmental stress, components of the neuro-immune system could be targets for developmental programming. However, little is known of any programming effects of developmental stress on neuro-immune function. We investigated whether developmental stress exposure via elevated pre-natal corticosterone (CORT) or post-natal unpredictable food availability, had long-term effects on pro (IL-1β) and anti-inflammatory (IL-10) cytokine and microglia-dependent gene (CSF1R) expression within HPA axis tissues in a precocial bird, the Japanese quail (Coturnix japonica). Following post-natal stress, we observed increased IL-1β expression in the pituitary gland, reduced IL-10 expression in the amygdala and hypothalamus and reduced CSF1R expression within the hypothalamus and pituita...
Source: Journal of Experimental Biology - Category: Biology Authors: Tags: RESEARCH ARTICLE Source Type: research