Is prenatal vitamin use by moms associated with risk for autism spectrum disorder recurrence in young siblings?

This study examined whether prenatal vitamin use by mothers was associated with autism spectrum disorder (ASD) recurrence in high-risk families. The study included 241 children who were selected because a sibling was diagnosed with ASD. Mothers reported their use of prenatal vitamins during pregnancy. While most mothers reported taking prenatal vitamins while pregnant, only 87 (36 percent) mothers met the recommendations to take prenatal vitamins in the six months before pregnancy.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 20 October 2019Source: Neurotoxicology and TeratologyAuthor(s): Rodrigo Moreno Klein, Camila Rigobello, Camila Borecki Vidigal, Kawane Fabrício Moura, Décio Sabbatini Barbosa, Daniela Cristina Ceccatto Gerardin, Graziela Scalianti Ceravolo, Estefânia Gastaldello MoreiraAbstractParacetamol (PAR) is an over-the-counter medicine used as analgesic or antipyretic by 40–50% of the pregnant women in different countries. Epidemiologic studies have been associating maternal use of PAR with neurodevelopmental disruption and special attention has been given to its potential...
Source: Neurotoxicology and Teratology - Category: Toxicology Source Type: research
This study contributes to the growing evidence of a link between prenatal exposure to air pollution and autism spectrum disorders, suggesting that prenatal exposure even below current WHO air quality guidelines may increase the risk of autism spectrum disorders. PMID: 31629172 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Abstract Single prenatal exposure to valproic acid (VPA) in rodents is a widely used preclinical model of autism spectrum disorder (ASD). Continuous prenatal VPA exposure has been recently proposed as a new ASD model that closely captures the neuropathological features of ASD, including increases in cerebral cortex volume and the number of cortical upper layer neurons. We investigated the influence of prenatal VPA exposure on the behavior of adult offspring of pregnant dams that received intraperitoneal injections of VPA twice on one day during the genesis of cortical upper layer neurons. Mice exposed to VPA at E1...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
Abstract BACKGROUND: Ambient air pollution and maternal diabetes may affect common biological pathways underlying adverse neurodevelopmental effects. However, joint effects of maternal diabetes and air pollution on autism spectrum disorder (ASD) have not been studied. OBJECTIVE: We evaluated whether prenatal and early-life air pollution exposure interacts with maternal diabetes status to affect ASD risk. METHODS: This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California hospitals in 1999-2009. Children were followed from birth until age 5, during wh...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
ConclusionsOur results showed that postnatal low-dose MK-801 improved ASD-associated behaviors in the VPA-treated rats and that early exposure to NMDA antagonist resulted in permanent changes in adult behavior.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
THURSDAY, Oct. 3, 2019 -- Many pregnant women suffer from morning sickness early in pregnancy. But a new study suggests that a small minority who suffer a more severe form of the illness may be at higher odds of having a child with autism. The form...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
We read with great interest the umbrella review of Dragioti et al in this issue of JAMA Psychiatry that evaluated 45 nonoverlapping meta-analyses of observational studies examining potential adverse health effects of antidepressant agents. In this review, the authors report that there is “convincing evidence” of 2 associations: (1) selective serotonin reuptake inhibitors (SSRIs) were associated with increased risk of suicide attempt or completion in children and adolescents, and (2) SSRI or antidepressant use during pregnancy was associated with autism spectrum disorder (ASD). L ike the authors, we believe that...
Source: JAMA Psychiatry - Category: Psychiatry Source Type: research
Abstract DOHaD (the Developmental Origins of Health and Disease) promises a greater understanding of early development but has left unresolved the balance of risks and benefits to offspring of medication use during pregnancy. Masarwa et al. (Am J Epi 2018;187(8):1817-1827) conducted a meta-analysis of the association between in utero acetaminophen exposure and risks for Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). A challenge of meta-analyzing results from observational studies is that summary measures of risk do not correspond to welldefined interventions when the individual...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Abstract Autism spectrum disorder (ASD) affects more boys than girls. Recent animal studies found that early life exposure to ambient particles caused autism-like behaviors only in males. However, there has been little study of sex-specificity of effects on ASD in humans. We evaluated ASD risk associated with prenatal and first year of life exposures to particulate matter less than 2.5 μm in aerodynamic diameter (PM2.5) by child sex. This retrospective cohort study included 246,420 singleton children born in Kaiser Permanente Southern California (KPSC) hospitals between 1999 and 2009. The cohort was followed ...
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Conclusions:Given that, increasing the age of marriage in Iran and recent trend towards delayed  childbearing; children born to older parents are at a higher risk for having ASD. So, increasing the  public awareness is necessary.Keywords:Autism spectrum disorder, mass screening, parent
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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