Liver Transplant Saves Critically Ill Patient

Treatment TermsAutoimmune HepatitisLiver transplant Overview Ray Thompson was a teenager when doctors first suspected something was wrong with his liver. He was an adult when he learned his condition was autoimmune hepatitis, a chronic disease in which the body ’s immune system attacks the liver. He kept it under control, but his luck ran out two years ago -- when he became so ill that he needed a liver transplant. While researching liver transplant programs, his wife discovered Duke was one of the best. Thompson was evaluated for the transplant and plac ed on the waitlist within one week of his first appointment. That remarkably fast turnaround is not uncommon at Duke. Hero Image2019_liver_raythomas_002.jpg Content Blocks CTA Header Learn More CTA ButtonLiver Transplantation Patient Name Ray Thompson Gender Male Patient Story Quote“Each day, I felt better. I could not have asked for better care." Featured Doctors Deepak Vikraman, MD BodyDisplay in Announcement Section:  Archived Medically Reviewed DateThursday, February 28, 2019 Reviewer Deepak Vikraman, MDPin to Top of WiFi Page: 
Source: Duke Health News - Category: Consumer Health News Authors: Source Type: news

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Conclusion: Our data suggest that mirtazapine can attenuate hepatic innate immune responses that critically regulate the subsequent development of autoimmune liver injury. Therefore, given that it is a safe and widely used medication, mirtazapine may represent a novel therapeutic approach to autoimmune liver disease. Introduction Classically, autoimmune disease was considered a disorder of adaptive immunity (1). However, early innate immune responses are clearly important for driving subsequent adaptive immune responses in autoimmunity. In numerous autoimmune disease models, activation of resident tissue macrophages,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Discussion The liver is one of the largest organs in the body, weighing just over 3 pounds in an adult. It is found in the upper right abdomen, under the right dome of the diaphragm. Grossly, it has asymmetric lobes with the right being larger than the left. The lobes are separated by a fibrous connective tissue band that also anchors the liver in the abdominal cavity. The gallbladder is located on the inferior surface of the liver and stores bile, which is then released into the duodenum. Microscopically, the liver cells are arranged in lobules with canals carrying blood vessels and bile ducts. At any moment about 10-13% ...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
ConclusionsNo chronic HEV infection was observed in our cohort of AIH patients. Anti ‐HEV‐IgG‐positive patients were older and the seroprevalence was nearly twice as high as reported previously in healthy Austrian individuals, suggesting that HEV‐infection might act as trigger for the development of autoimmune hepatitis.This article is protected by copyright. All rights reserved.
Source: Liver International - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
CONCLUSIONS.—: Characteristic microscopic findings in EBV hepatitis include a diffuse lymphocytic sinusoidal infiltrate in a "string of beads" pattern, expansion of portal tracts by a predominantly lymphocytic infiltrate, and intact lobular architecture. In situ hybridization of EBV-encoded RNA is a helpful ancillary test. Correlation of clinical history, laboratory findings, and histopathologic features is essential to distinguish EBV hepatitis from autoimmune liver diseases, transplant rejection, lymphomas, and drug-induced liver injury. PMID: 30281361 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
We report 4 cases of de novo autoimmune hepatitis after living donor liver transplantation (LDLT).
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Semin Liver Dis 2017; 37: 343-362 DOI: 10.1055/s-0037-1607453Several salvage therapies have been identified for autoimmune hepatitis refractory or recalcitrant to conventional therapy; however, the optimal salvage strategy remains unclear. High-dose prednisolone is currently recommended as the front-line salvage therapy, with alternative immunosuppressive therapies reserved for continuing treatment failure. Of the second-line therapies, the calcineurin inhibitors, cyclosporine and tacrolimus, and mycophenolate mofetil are preferred and have the most accrued clinical data. However, none of these have undergone rigorous clin...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
Publication date: Available online 24 November 2016 Source:Pediatria Polska Author(s): Kamil Janowski, Maciej Pronicki, Wiesława Grajkowska, Piotr Kaliciński, Piotr Socha Histopathological examination of the liver is used to diagnose, stage, prognose and monitore many liver diseases. Indications to the liver biopsy in children may vary. Percutaneous and surgical biopsies are the most frequently performed procedures in native or in transplanted liver, in explanted and partially resected organs. The aim of this study is to review all of histopathological liver examinations performed in Children's Memorial Health Institute...
Source: Pediatria Polska - Category: Pediatrics Source Type: research
(Wiley) New research indicates that mycophenolate mofetil, a drug that is usually used to prevent rejection after kidney, heart or liver transplant, seems safe and effective in treating autoimmune hepatitis, a serious chronic liver disease that mainly affects women.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as evidenced by jaundice, elevated liver enzymes, and increased bilirubin. Liver biopsy showed histology suggestive of autoimmune-like hepatitis, which is a rare manifestation of chronic "hepatitic" graft versus host disease.
Source: International Journal of Surgical Pathology - Category: Pathology Authors: Tags: Case Reports Source Type: research
In this report, we discuss a case of HPS complicated AIH in a pediatric patient and review the relevant literature.
Source: Pediatric Transplantation - Category: Transplant Surgery Authors: Tags: Case Report Source Type: research
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