LEKTI domains 6, 7 and 8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome.

CONCLUSION: There are specific domains of LEKTI, which are recognized and processed by transglutaminase 1. LEKTI domains D6, D7 and D8+9 contribute to the formation and protection of the cornified envelope. These results impact the development of protein replacement therapy approaches for Netherton syndrome. This article is protected by copyright. All rights reserved.
PMID: 30801672 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - February 22, 2019 Category: Dermatology Authors: Wiegmann H, Valentin F, Tarinski T, Liebau E, Loser K, Traupe H, Oji V Tags: Br J Dermatol Source Type: research