Waldenstr öm Macroglobulinemia: Unusual Presentation With Cast Nephropathy/Light Chain Tubulopathy.

We present an interesting case of Cast Nephropathy and light chain tubulopathy in an 81-year-old female patient with Waldenstrom Macroglobulinemia who required medical attention for worsening renal failure. Serum protein electrophoresis/Immunofixation showed IgM Kappa monoclonal gammopathy. Renal biopsy was remarkable for cast nephropathy and light chain tubulopathy. Furthermore on bone marrow biopsy a low grade B cell lymphoproliferative disorder with plasmacytic differentiation was present. This was most consistent with lymphoplasmacytic lymphoma, accounting for 50-60 percent of total bone marrow cellularity, in a hypercellular (60-80 percent) bone marrow. PMID: 30799965 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30799965?dopt=Abstract

Source: Clinical Lymphoma and Myeloma - February 27, 2019 Category: Cancer & Oncology Authors: Ashraf M, Rastogi P Tags: Clin Med Insights Case Rep Source Type: research