Negative Regulation of Cytosolic Sensing of DNA.

Negative Regulation of Cytosolic Sensing of DNA.
Int Rev Cell Mol Biol. 2019;344:91-115
Authors: Abe T, Shapira SD
Abstract
In mammals, cytosolic detection of nucleic acids is critical in initiating innate antiviral responses against invading pathogens (like bacteria, viruses, fungi and parasites). These programs are mediated by multiple cytosolic and endosomal sensors and adaptor molecules (c-GAS/STING axis and TLR9/MyD88 axis, respectively) and lead to the production of type I interferons (IFNs), pro-inflammatory cytokines, and chemokines. While the identity and role of multiple pattern recognition receptors (PRRs) have been elucidated, such immune surveillance systems must be tightly regulated to limit collateral damage and prevent aberrant responses to self- and non-self-nucleic acids. In this review, we discuss recent advances in our understanding of how cytosolic sensing of DNA is controlled during inflammatory immune responses.
PMID: 30798991 [PubMed - in process]

Source: International Review of Cell and Molecular Biology - February 27, 2019 Category: Cytology Authors: Abe T, Shapira SD Tags: Int Rev Cell Mol Biol Source Type: research