Metastasis Stemming from Circulating Tumor Cell Clusters.

Metastasis Stemming from Circulating Tumor Cell Clusters.
Trends Cell Biol. 2019 Feb 21;:
Authors: Yu M
Abstract
Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela et al. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel insights into the epigenetic regulation of 'stemness' in CTC clusters.
PMID: 30799250 [PubMed - as supplied by publisher]

Source: Trends in Cell Biology - February 21, 2019 Category: Cytology Authors: Yu M Tags: Trends Cell Biol Source Type: research