Commentary: T cells regulate lung transplant rejection in mice and men

Since the advent of lung transplantation, chronic lung allograft dysfunction (CLAD) has been the number one cause of long-term mortality.1 A subset of T cells, known as regulatory T cells (Tregs), have been shown to suppress inflammatory responses after organ transplantation. Much of what is known about the role of Tregs in suppressing alloimmune responses has come from experimental studies of kidney, heart, pancreatic islet, liver, and bone marrow transplantation. On the basis of these findings, 2 phase I clinical trials in which adoptively transferred Tregs were administered after kidney transplantation have been completed.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research