Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1 α Pathway in Zucker Diabetic Fatty Rats

ConclusionOur data demonstrate that sphingolipid balance, and increased AMPK, SIRT1, PGC-1 α, and CS protein expression are part of the mechanism that contributes to the remission of diabetes after RYGB surgery.

http://link.springer.com/10.1007/s11695-019-03800-z

Source: Obesity Surgery - February 26, 2019 Category: Surgery Source Type: research