Discovery of new Phosphoinositide 3-kinase delta (PI3K δ) inhibitors via virtual screening using crystallography-derived pharmacophore modelling and QSAR analysis.

CONCLUSIONS: Crystallography-based pharmacophores were successfully combined with QSAR analysis for the identification of novel PI3Kδ inhibitors. PMID: 30799792 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30799792?dopt=Abstract

Source: Medicinal Chemistry - February 22, 2019 Category: Chemistry Authors: Al-Sha Er MA, Al-Aqtash RAA, Taha MO Tags: Med Chem Source Type: research

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