Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related receptor- α.

CONCLUSION: The synthetic RORα-selective inverse agonists identified (20, 28) can be utilized as chemical tools to probe the function of RORα in vitro and in vivo.
PMID: 30799793 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - February 22, 2019 Category: Chemistry Authors: Doebelin C, He Y, Campbell S, Nuhant P, Kumar N, Koenig M, Garcia-Ordonez R, Chang MR, Roush WR, Lin L, Kahn S, Cameron MD, Griffin PR, Solt LA, Kamenecka TM Tags: Med Chem Source Type: research