Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents.

CONCLUSION: This report describes the total and facile synthesis of modified furanononucleosides of uracil, with alterations on both the sugar and the heterocyclic portions. Compounds 12b, 14 and 18a,c,d showed noticeable antiviral activity against a series of RNA viruses and merit further biological and structural optimization investigations.
PMID: 30799795 [PubMed - as supplied by publisher]

Source: Medicinal Chemistry - February 24, 2019 Category: Chemistry Authors: Kollatos N, Mitsos C, Manta S, Tzioumaki N, Giannakas C, Alexouli T, Panagiotopoulou A, Schols D, Andrei G, Komioti D Tags: Med Chem Source Type: research