Distinguishing metastases from benign adrenal masses: what can CT texture analysis do?

Distinguishing metastases from benign adrenal masses: what can CT texture analysis do? Acta Radiol. 2019 Feb 24;:284185119830292 Authors: Shi B, Zhang GM, Xu M, Jin ZY, Sun H Abstract BACKGROUND: Computed tomography texture analysis (CTTA) has gained an increasing role in oncology and has successfully demonstrated to reflect biological associations with glucose metabolism, hypoxia, angiogenesis, and even genetic variation. PURPOSE: To determine whether quantitative CTTA can be used to differentiate metastases from benign adrenal masses on single energy CT images. MATERIAL AND METHODS: A total of 225 patients with 265 histologically confirmed adrenal masses (101 metastases, 98 pheochromocytomas, and 66 lipid-poor adenomas) were included in this retrospective study. CTTA was performed and six texture parameters (including mean, SD of pixel distribution histogram, mean of positive pixels, entropy, kurtosis, skewness) across six spatial scaling factor (SSF) were recorded on both unenhanced and contrast-enhanced CT images. Receiver operating characteristic (ROC) analysis was performed and the area under the ROC curve (AUC) was calculated using the significant texture parameters for the objective. Diagnostic performance was evaluated using the cut-off values of texture parameters by ROC analysis. The optimal discriminative texture parameters were used to produce support vector machine (SVM) classifiers. Diagnostic accuracy and 10-fold cross-validatio...
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

Related Links:

Conclusions [68Ga]DOTANOC PET/CT should be considered as a first-line investigation in PCC/PGL especially at high risk of metastasis and screening of persons with familial syndrome.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Conclusion: We report a family with a new clinical phenotype of germline pathogenic variants in MAX who developed both PCC and GN. Germline pathogenic variants in MAX may contribute to the development of GN. Our findings suggest that it is not just paternally inherited MAX variants that can cause tumors.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: The combined epidural-general anesthesia was not effective in attenuating hypertensive responses, but could have exacerbated intraoperative hypotension. These findings should be taken into account before selecting the anesthetic technique in pheochromocytoma and sympathetic paraganglioma surgery. PMID: 32788874 [PubMed - as supplied by publisher]
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Phaeochromocytoma and paraganglioma (PPGL) are chromaffin cell tumours that require timely diagnosis because of their potentially serious cardiovascular and sometimes life- threatening sequelae. Tremendous progress in biochemical testing, imaging, genetics and pathophysiological understanding of the tumours has far-reaching implications for physicians dealing with hypertension and more importantly affected patients. Because hypertension is a classical clinical clue for PPGL, physicians involved in hypertension care are those who are often the first to consider this diagnosis. However, there have been profound changes in ho...
Source: Journal of Hypertension - Category: Cardiology Tags: CONSENSUS DOCUMENT Source Type: research
Authors: Longoria-Dubocq T, Torres-Aguiar R, Ruiz-Vega K, De Ayala-Hillmann R, Lopez-Enriquez R Abstract Adrenal incidentalomas are tumors located in the adrenal glands and found on imaging done for purposes not related to adrenal disease. In other cases adrenal mases can be radiologically found when an adrenal hormone secreting tumor is suspected, such as a pheochromocytoma or Cushing's diseases. Adrenal incidentalomas may be classified as functional or non-functional based on whether they produce hormones, such as aldosterone, cortisol, and androgens, or catecholamines. Studies indicate that around 8% of adrenal ...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
This report reminds us to pay close attention to the likelihood of ectopic pheochromocytoma and other low-incidence diseases. Physicians and imaging clinicians should explore all clinical possibilities to avoid missed diagnosis or misdiagnosis of ectopic pheochromocytoma and take effective treatment measures to maximize patient benefits.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion: This report represents the first description of a co-occurrence of multiple composite PCC-GN and neuroblastic tumors. The long timeline of the presentation of the NENs/neuroblastic tumors from infancy to adulthood requires a lifelong follow-up for this patient. Moreover, the importance of this case lies in the presence of a novel MAX gene variant deleterious, harmful, and causative of pathology, confirmed by Sanger sequencing and never been associated before with multiple composite PCC-GN. The present case underlines the importance of precision medicine and molecular diagnoses for hereditary pheochromocytomas a...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
125Aim: The aim of this study was to evaluate and compare the diagnostic performance of 68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) positron emission tomography-computed tomography (PET/CT) to 18F-fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT and magnetic resonance imaging (MRI) of cervical, thoracic, and lumbar spine for the detection of spinal bone metastases in metastatic pheochromocytoma and/or paraganglioma (PPGL). Methods: A total of 47 consecutive metastatic PPGL patients underwent MRI (sagittal T1w, sagittal STIR, axial T1w, and axial T2w) of the cervical, thoracic, and lumbar spine for the evaluation of spinal bone...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NET and Others II Source Type: research
Conclusions: Our results show that 68Ga-DOTANOC PET/CT may be a useful modality for screening and follow up of associated tumours in patients with germline gene mutation for VHL.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NET and Others II Source Type: research
AbstractAsk-Upmark kidney (AUK) is a scarred segment of the kidney, characterized by formation of primitive tubular and glomerular structures, and sporadically diagnosed as a cause of hypertension (HTN). A 6-year-old girl with neurofibromatosis type 1 (NF1) and moyamoya syndrome had severe HTN. Based on past history, she had HTN at the age of 1.5  years. Laboratory examination revealed slightly elevated plasma and renal venous renin activity without lateralization. No evidence of pheochromocytoma, or coarctation of the aorta was found. Contrast-enhanced computed tomography (CT) showed an area of hypoperfusion in the u...
Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
More News: Cancer & Oncology | CT Scan | Genetics | Pheochromocytoma | Study