Distinguishing metastases from benign adrenal masses: what can CT texture analysis do?

Distinguishing metastases from benign adrenal masses: what can CT texture analysis do? Acta Radiol. 2019 Feb 24;:284185119830292 Authors: Shi B, Zhang GM, Xu M, Jin ZY, Sun H Abstract BACKGROUND: Computed tomography texture analysis (CTTA) has gained an increasing role in oncology and has successfully demonstrated to reflect biological associations with glucose metabolism, hypoxia, angiogenesis, and even genetic variation. PURPOSE: To determine whether quantitative CTTA can be used to differentiate metastases from benign adrenal masses on single energy CT images. MATERIAL AND METHODS: A total of 225 patients with 265 histologically confirmed adrenal masses (101 metastases, 98 pheochromocytomas, and 66 lipid-poor adenomas) were included in this retrospective study. CTTA was performed and six texture parameters (including mean, SD of pixel distribution histogram, mean of positive pixels, entropy, kurtosis, skewness) across six spatial scaling factor (SSF) were recorded on both unenhanced and contrast-enhanced CT images. Receiver operating characteristic (ROC) analysis was performed and the area under the ROC curve (AUC) was calculated using the significant texture parameters for the objective. Diagnostic performance was evaluated using the cut-off values of texture parameters by ROC analysis. The optimal discriminative texture parameters were used to produce support vector machine (SVM) classifiers. Diagnostic accuracy and 10-fold cross-validatio...
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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This study had been originally carried out as a project of a research proposed on behalf of the Japanese Ministry of Health, Labour and Welfare, from 1999 to 2004. This nationwide multicenter study on AIs included 3,672 cases with clinically diagnosed AIs, involving 1,874 males and 1,738 females, with mean age 58.1 ± 13.0 years (mean ± SD). In the present study, we focused on the investigation of the real prevalence of various adrenal disorders with AI. The mean nodule size of AI based on computed tomography was 3.0 ± 2.0 cm. Compared to non-functioning adenomas (NFAs), tumor diameters were significant...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
A 52-year-old male who had chronic hypertension for several years presented with abrupt epistaxis. The CT scan revealed a 40 mm × 40 mm mass in the nasal cavity intended to the maxillary sinus and the base of skull. Nasal endoscope biopsy and serum/urinary catecholamine detection conformed an ectopic noradrenaline-secreting pheochromocytoma. The present research was to discuss the clinical characteristics of the rare pheochromocytoma and the palliative interventional embolization for it.
Source: Journal of Craniofacial Surgery - Category: Surgery Tags: Clinical Studies Source Type: research
ConclusionPheochromocytomas is a rare disease which may lead to a life-threathening hypertension as a result of elevated cathecolamine production. Initial recognition and appropriate management of pheochromocytomas are important. Preoperative management to normalize blood pressure followed by tumor removal has proved to be the ideal choice for good prognosis. Multidisciplinary team during preoperative, intraoperative and postoperative are required for successful outcome.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Purpose: To evaluate the safety and clinical effectiveness of computed tomography (CT)-guided cryoablation for adrenal pheochromocytoma (AP). Materials and Methods: From July 2015 to October 2018, we observed 8 patients that underwent CT-guided cryoablation for AP. The blood pressure and pulse before treatment did not exceed 150/90 mm Hg and 90 times/min, respectively. Complete ablation rate, clinical success rate, and long-term outcomes were analyzed. Results: A total of 8 patients with 8 APs were treated by CT-guided cryoablation. The mean duration of the procedure was 67.5±4.6 minutes...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
Publication date: Available online 8 September 2019Source: Journal of Cardiology CasesAuthor(s): Hiroaki Kawano, Takao Ando, Yohei Shida, Daisuke Niino, Koji Maemura, Kioko KawaiAbstractA 44-year-old Japanese man was referred to our hospital for the evaluation of paroxysmal hypertension. 123I-metaiodobenzylguanidine (MIBG) single-photon emission computed tomography (SPECT) revealed specific uptake in the left adrenal gland in addition to high levels of serum and urinary catecholamines although computed tomography and magnetic resonance imaging were not able to detect a definite adrenal mass. Left adrenalectomy was performe...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
To assess the diagnostic accuracy of unenhanced computed tomography (CT) attenuation values to exclude a pheochromocytoma in the diagnostic work-up of patients with an adrenal incidentaloma and to model the associated difference in diagnostic costs.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Original article Source Type: research
ConclusionSince the European Association of Nuclear Medicine 2012 guidelines, the excellent results obtained with gallium-68 (68Ga)-labelled somatostatin analogues (SSAs) in recent years have simplified the imaging approach for PPGL patients that can also be used for selecting patients for peptide receptor radionuclide therapy as a potential alternative or complement to the traditional theranostic approach with iodine-123 (123I)/iodine-131 (131I)-labelled meta-iodobenzylguanidine. Genomic characterisation of subgroups with differing risk of lesion development and subsequent metastatic spread is refining the use of molecula...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
CONCLUSION: Brown fat activation may mislead diagnosis of pheochromocytoma, suggesting multi-metastatic extra-adrenal tumor, if clinicians are not aware of it. PMID: 31606198 [PubMed - as supplied by publisher]
Source: Annales d'Endocrinologie - Category: Endocrinology Authors: Tags: Ann Endocrinol (Paris) Source Type: research
ConclusionEndocrine HT has many etiologies possibly responsible for high morbidity and mortality, especially when not properly diagnosed or treated. The potentially curable nature of endocrine HT in more than two thirds of cases, demonstrates the importance of early diagnosis of every severe HT resistant to treatment or in the presence of suggestive clinical, biological or radiological signs.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Rationale: It is difficult to discriminate malignant pheochromocytoma (PCC) from benign PCC. The requirement of abdominal aortic and inferior vena cava reconstruction is extremely rare. Patient concerns: We here report a case of a large pheochromocytoma in a 56-year-old woman who complained of only hand trembling and had no hypertension or other symptoms. The operation was difficult because of a tight adhesion to the circumference of great vessels. A replacement of the aortocaval vessels with grafts was necessary to remove the tumor completely. Diagnoses: Ultrasonography, computed tomography (CT), and catecholamine...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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