Hyperlipidemia and Allograft Rejection

AbstractPurpose of ReviewAdvances in the development of immunosuppressive drug regimens have led to impressive survival rates in the year following organ transplantation. However, rates of long-term graft dysfunction remain undesirably high. Recently, it has been shown that co-morbidities in the patient population may affect graft survival. In mouse models, hyperlipidemia, a co-morbidity present in the majority of cardiac transplant patients, can significantly alter T cell responses to cardiac and skin allografts and accelerate graft rejection. Here, we review recent advances in our understanding of how alterations in lipids affect immune function and graft survival.Recent FindingsRecent work in humans has highlighted the importance of controlling low-density lipoprotein (LDL) levels in transplant recipients to reduce the development of chronic allograft vasculopathy (CAV). High serum levels of cholesterol containing particles lead to extensive immune system changes to T cell proliferation, differentiation, and suppression. Changes in B cell subsets and the ability of antigen presenting cells to stimulate T cells in hyperlipidemic animals may also contribute to increased organ allograft rejection.SummaryCholesterol metabolism is a critical cellular pathway for proper control of immune cell homeostasis and activation. Increasing evidence in both human and in mouse models shows that elevated levels of serum cholesterol can have a profound impact on the immune system. Hyperlipid...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Contributors : N H Ly ; T Maekawa ;  K Yoshida ; Y Liu ; M Muratani ;  S IshiiSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusIncreasing evidence indicates that parental diet affects the metabolism and health of offspring. It is reported that paternal low-protein diet (pLPD) induces glucose intolerance and the expression of genes involved in cholesterol biosynthesis in mouse offspring liver. The aim of the present study was to determine the effect of a pLPD on gene expression in offspring white adipose tissue (WAT), another important tissue for the regulation of metabolism. ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsAmong both patient groups, phentermine was more effective in achieving weight loss. Lorcaserin had dyslipidemia improvements only, among surgical patients who achieved significant weight reduction. Anti-obesity medications as part of weight management programs can result in weight loss among non-surgical and surgical patients, or halt weight regain among surgical patients.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 13 July 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Nadia Hamjane, Fatiha Benyahya, Mohcine Bennani Mechita, Naima Ghailani Nourouti, Amina BarakatAbstractAimThe aim of this work was to study overweight and obesity and their associated complications according to obesity indicators in a population of Tangier.MethodsA total of 480 overweight and obese patients were included in this study, referred to hospital Duc Tovar of Tangier during a period of 12 months. The collection of data has been done through a questionnaire which included anthropometric...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 8 May 2019Source: Canadian Journal of DiabetesAuthor(s): Ivana Resanović, Zoran Gluvić, Božidarka Zarić, Emina Sudar-Milovanović, Vesna Vučić, Aleksandra Arsić, Olgica Nedić, Miloš Šunderić, Nikola Gligorijević, Davorka Milačić, Esma R. IsenovićAbstractObjectiveMetabolic changes in insulin-dependent diabetes mellitus (IDDM) impair vasodilation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in IDDM patients and reduce vascular complications. The aim of o...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
In conclusion, pronounced EPS production, exemplary functional and technological traits, and safety aspects signify suitability of L. plantarum strain AAS3 in food processing industries as quintessential adjunct/starter culture.
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 12 July 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Vivian Jordania da Silva, Sílvia Regina Costa Dias, William Pereira Alves, Luis Fernando Viana Furtado, Luciana Ribeiro Serafim, Thayse Batista Moreira, Pedro Henrique Nascimento de Aguiar, Ana Maria Caetano de Faria, Élida Mara Leite RabeloAbstractObesity and ancylostomiasis are considered public health problems. Recent studies have shown that infection by intestinal helminths in obese individuals can ameliorate metabolic disorder and improve glucose tolerance by decreasing both insulin resistance and low-...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
In conclusion, our results showed that serum Apelin-36 concentration decreased after parturition in dairy cow. Alteration of Apelin-36 secretion after parturition may represent an endocrine adaptation in dairy cow during the lactating period.
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Publication date: Available online 13 July 2019Source: Journal of Thermal BiologyAuthor(s): Eric Rivas, Craig G. Crandall, Oscar E. Suman, Naima Moustaid-Moussa, Vic Ben-EzraAbstractBackgroundPassive hyperthermic exposure causes an acute hypotensive response following the cessation of heat stress. Chronic heat stress is well documented in animal studies to instigate metabolic and lipid alterations. However, it is unknown if exercise-heat acclimation also causes favorable chronic blood pressure, lipid, and immune responses in humans.PurposeThis project tested the hypothesis that 10-day exercise-heat acclimation (HA) would c...
Source: Journal of Thermal Biology - Category: Biology Source Type: research
Authors: Cocoman AM, Gallagher D Abstract Individuals who are treated with antipsychotic medications are at risk of developing metabolic syndrome (MetS). The comorbidity of a severe mental illness (SMI) and a physical illness has a major impact on the quality of life of these individuals. We conducted a retrospective chart review (RCR) of 214 individuals with a diagnosis of schizophrenia who had been receiving antipsychotic medications for at least 6 months, in five clinical settings in an Irish community mental health service. The aim was to determine the presence of MetS to assist in improving screening pr...
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
ConclusionMetabolic changes were more pronounced in animals submitted to a continual hypocaloric diet, but physical activity proved to be beneficial with regard to some of the analyzed variables.
Source: Sport Sciences for Health - Category: Sports Medicine Source Type: research
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