Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.

CONCLUSIONS: Immunization with native antigens might not be sufficient to obtain complete protection to infection. Nonetheless we showed that non-infectious B. burgdorferi can be an effective carrier to deliver and elicit a specific host response to T. pallidum antigens to assess the efficacy of syphilis vaccine candidates. PMID: 30797635 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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This article discusses a quality improvement project across four NP-owned primary care clinics in which all clinical staff received an educational intervention focused on best vaccination practices and Medicare billing strategies. This project yielded improved vaccination rates in the older adult patient population over a 3-month period.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: PREVENTIVE CARE: DNP SPECIAL ISSUE Source Type: research
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This study sought to compare the efficacy of any 5-NI with any other antigiardial drug for the treatment of Cuban children with giardiasis. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). We searched CUMED, EBSCOhost and PubMed databases. Two reviewers independently assessed trial eligibility, trial quality and extracted appropriate data. The primary outcome was the parasitological cure. The effect estimate was the pooled relative risk (RR) with 95% confidence intervals (CI). We included seven RCTs in the systematic review, involving a total of 1046 children. When the effect of 5-...
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Publication date: June 2019Source: Carbon, Volume 147Author(s): Li Zhi Guan, María C. Gutiérrez, Luís Yuste, Fernando Rojo, M. Luisa Ferrer, Francisco del MonteAbstractVortex ring (VR) processes have proved highly effective in tailoring the morphology/shape of particles prepared from nanoclays, silica nanocolloids, magnetic nanoparticles and different polysaccharides. Herein, we have prepared toroidal-, teardrop-, jellyfish-, and cap-shaped vortex ring particles by dripping an aqueous suspension of graphene oxide (GO) into a cetyl trimethylammonium bromide (CTAB) aqueous solution that played the role o...
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As chair of general pediatrics for a large medical group, I knew our HPV vaccination rates back in 2016 were low, but didn ’t completely understand why. I’m here to share how we figured it out, and how we improved. The first task was to understand the barriers, and we went straight to the front line. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
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Authors: Ogane H, Sato TA, Shinokawa C, Sawai J Abstract  The effect of food preservatives and sanitizers at low concentrations on the induction of Escherichia coli into a viable but nonculturable (VBNC) state was investigated. When E. coli was incubated in physiological saline at 37℃, the viable cell count measured by plate counting was approximately 3-logs lower than that measured by flow cytometry after 30 days. This difference, and morphological changes in cells, confirmed the transition of E. coli into a VBNC state. Adding 10 μg/l of sorbic acid significantly promoted the induction of E. coli into a VBN...
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Authors: Tanaka N, Hatano T, Saito S, Wakabayashi Y, Abe T, Kawano Y, Ohtsu I Abstract Many organisms produce endogenous hydrogen sulfide (H2S) as a by-product of protein, peptide, or L-cysteine degradation. Recent reports concerning mammalian cells have demonstrated that H2S acts as a signaling molecule playing important roles in various biological processes. In contrast to mammals, bacterial H2S signaling remains unclear. In this work, we demonstrate that Escherichia coli generates H2S through the assimilation of inorganic sulfur, without L-cysteine degradation. Comparison of phenotypes and genomes between labora...
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