Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.
CONCLUSIONS: Immunization with native antigens might not be sufficient to obtain complete protection to infection. Nonetheless we showed that non-infectious B. burgdorferi can be an effective carrier to deliver and elicit a specific host response to T. pallidum antigens to assess the efficacy of syphilis vaccine candidates. PMID: 30797635 [PubMed - as supplied by publisher]
Publication date: Available online 17 September 2020Source: Protein Expression and PurificationAuthor(s): Zeynep Efsun DUMAN, Aişe ÜNLÜ, Hayriye ÜNAL, John M. WOODLEY, Barış BİNAY
Number of cases worldwide passes 30 million; Victoria announces 21 new Covid-19 cases and seven more deaths; UK faces possible second national lockdown. Follow all the developmentsMutant virus: should we be worried that Sars-CoV-2 is changing ?UK entering second wave of virus, Johnson warns‘Shocking’: Trump under fire from ex-adviser for Covid failures5.31amBSTThe Victorian Department of Health and Human Services has put out some more information on the latest case numbers today.The 21 cases is the lowest number of new cases since 24 June.Of the 834 current active cases in Victoria:5.12amBSTThe Australian minis...
US president’s prediction comes as CDC reverses course on testing guidelines
President Trump acknowledged that an authorized vaccine for ‘every American’ may not be distributed until next year. An Iranian official says the country has become a “red zone” as cases and deaths surge.
In this study, the proteome changes of Escherichia coli (E. coli) continuously induced in concentrations of 1.0 mg/L and 10.0 mg/L polymyxin B were revealed. Compared to E. coli (PMB0), E. coli exposed to polymyxin B at 1.0 mg/L (PMB1) and 10.0 mg/L (PMB10) resulted in 89 and 314 differentially expressed proteins (DEPs), respectively. Such differences related to fatty acid degradation, quorum sensing and two-component regulatory system pathways. Based on absolute quantitative (iTRAQ) proteomics analysis, this study comprehensively studied the changes of E. coli proteome in culture wi...
The viruses' symptoms are similar, making it hard to distinguish between them. Doctors are urging people to get the annual flu vaccine to prevent a "twindemic" this fall and winter.
Companies are struggling to recruit diverse volunteers in final U.S. tests of possible COVID-19 vaccines
Publication date: Available online 18 September 2020Source: Progress in Natural Science: Materials InternationalAuthor(s): Zonghua Liu, Linghong Huang, Wei Xue
The president has contradicted health experts, and now his own ambitious timeline, for a vaccine against COVID-19.(Image credit: Alex Wong/Getty Images)