Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.

CONCLUSIONS: Immunization with native antigens might not be sufficient to obtain complete protection to infection. Nonetheless we showed that non-infectious B. burgdorferi can be an effective carrier to deliver and elicit a specific host response to T. pallidum antigens to assess the efficacy of syphilis vaccine candidates. PMID: 30797635 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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This study demonstrated that there was a higher abundance of sRNA in the pig farm WWTPs and 52 sRNAs were detected. The sRNAs were mainly present in Proteobacteria and Firmicutes, including the potential human pathogenic bacteria (HPB) (Escherichia, Shigella, Bordetella and Morganella), crop pathogen (Pectobacterium) and denitrifying bacteria (Zobellella). And the sRNAs were involved in the bacterial functional activities such as translation, transcription, drug resistance, membrane transport and amino acid metabolism. In addition, most sRNAs had a higher abundance in anoxic tanks which contained a higher abundance of the ...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
In this study, an analysis of the potential mechanism underlying photocatalytic disinfection was performed based on integrated metabolic networks and transcriptional data. Two sets of RNA-seq data (wild type and a photocatalysis-resistant mutant mediated by titanium dioxide (TiO2)) were processed to constrain the genome scale metabolic models (GSMM) of E. coli. By analyzing the metabolic network, the differential metabolic flux of every reaction was computed in constrained GSMM, and several significantly differential metabolic fluxes in reactions were extracted and analyzed. Most of these reactions were involved in the tra...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
Conclusions: This municipality needs to reach mothers with lower socioeconomic status, restructure the local health services, and enhance their operationalization to improve the quality of prenatal care.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Researchers look to messenger RNA encased in nanoparticles, DNA plasmids, molecular clamps, and other approaches as they rush to design a vaccine against the new coronavirus.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Publication date: Available online 20 February 2020Source: The Lancet Global HealthAuthor(s): Xin Wang, You Li, Katherine L O'Brien, Shabir A Madhi, Marc-Alain Widdowson, Peter Byass, Saad B Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W Abdullah Brooks, Sandra S Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A Fasce, Angela Gentile, Aubree GordonSummaryBackgroundSeasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-viru...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
AbstractWhen deciding whether to vaccinate, people often seek information through consequential processes that are not currently well understood. A survey of a nationally representative sample of U.S. adults (N = 2,091) explored the factors associated with intentions to seek influenza vaccine information in the 2018 –2019 influenza season. This survey shed light on what motivates intentions to seek information about the influenza vaccine through the lens of the risk information seeking and processing (RISP) model. The model explained information‐seeking intentions well among both unvaccinated and vaccinated respond...
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research
Publication date: Available online 21 February 2020Source: Sensing and Bio-Sensing ResearchAuthor(s): Alisher Sultangaziyev, Aktilek Akhmetova, Zhanar Kunushpayeva, Alisher Rapikov, Olena Filchakova, Rostislav BukasovAbstractVery high surface/metal enhanced fluorescence was observed for E. coli single bacteria cells labeled with composite CdSeS/ZnS quantum dots (QDs) on three substrates: aluminum foil, aluminum film and gold film. The enhancement factors relative to maximum fluorescence intensity on glass for those substrates were in the range of several hundred (up to 500) for two-excitation wavelengths 532 and 633 nm. ...
Source: Sensing and Bio Sensing Research - Category: Research Source Type: research
"Your child is due for shots today," is frequently followed in my practice by a grimace and a visible tightening of parents' hold on their baby. Then comes my rehearsed recital of the diseases against which we are protecting the baby through vaccination and lastly, I lay out the total number of shots due. That is when the bargaining starts -- "Does she really need that many Dr. Bracho? Couldn't we do two today and the rest next time?"
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Condition:   Glioblastoma Intervention:   Drug: UCPVax Sponsor:   Centre Hospitalier Universitaire de Besancon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Primary Prevention Interventions:   Behavioral: Boot Camp Translation;   Other: Control Sponsors:   University of Colorado, Denver;   National Institutes of Health (NIH);   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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