Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis

Conditions:   HIV Infections;   Tuberculosis Interventions:   Other: Placebo;   Drug: Dolutegravir 50 mg Sponsors:   University of Cape Town;   Wellcome Trust;   Medecins Sans Frontieres, Netherlands Not yet recruiting
Source: - Category: Research Source Type: clinical trials

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In this study, we have synthesized four heterocyclic azo dyes by conventional diazo-coupling reaction between aniline derivatives with 5-methyl-2-(6-methyl-1,3-benzothiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one at lower temperatures and are characterized by physico-chemical techniques. The quantum chemical study was also employed to understand the chemical reactivity of the compounds by using B3LYP method in conjunction with 6–31G (d, p) basis set. The photochemical property of the dyes was studied and they showed higher intensity and good quantum yield with respect to the Rhodamine B. The azo dyes were screened for the...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 13 December 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Valnês S. Rodrigues-Junior, Anne D. Villela, Bruno L. Abbadi, Nathalia D.M. Sperotto, Kenia Pissinate, Jaqueline N. Picada, Juliana Bondan da Silva, Cristiano V. Bizarro, Pablo Machado, Luiz A. BassoAbstractNew effective compounds to treat tuberculosis are urgently needed. IQG-607 is an orally active anti-tuberculosis drug candidate, with promising preliminary safety profile and anti-mycobacterial activity in both in vitro and in vivo models of tuberculosis infection. Here, we evaluated the mutagenic and genoto...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
Authors: Twumasi C, Asiedu L, Nortey ENN Abstract Several mathematical and standard epidemiological models have been proposed in studying infectious disease dynamics. These models help to understand the spread of disease infections. However, most of these models are not able to estimate other relevant disease metrics such as probability of first infection and recovery as well as the expected time to infection and recovery for both susceptible and infected individuals. That is, most of the standard epidemiological models used in estimating transition probabilities (TPs) are not able to generalize the transition esti...
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Structural BiologyAuthor(s): Nina T. Odermatt, Moreno Lelli, Torsten Herrmann, Luciano A. Abriata, Aleksandre Japaridze, Hubert Voilquin, Rajkumar Singh, Jérémie Piton, Lyndon Emsley, Giovanni Dietler, Stewart T. ColeAbstractIn bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to Actinobacteria and essential for survival of the human pathog...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Authors: Abad CL, Razonable RR Abstract INTRODUCTION: Tuberculosis (TB) in solid organ transplant (SOT) recipients is associated with significant morbidity and mortality. Its management in transplant recipients is difficult and highly complex, given the underlying immunosuppression and the risks of drug-drug interactions imposed by immunosuppressive drugs that are needed to maintain the transplant allograft.Areas covered: We provide a brief review of TB in SOT, and discuss the clinical indications, mechanisms of action and drug resistance, drug-drug interactions, and adverse effects of anti-TB drugs. We provide a s...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
We present a case of Collecting duct of Bellini carcinoma (CDC) which was masquerading as Genitourinary Tuberculosis/chronic granulomatous disease in a 43 year old women, who presented with complaints of low grade fever, loss of appetite, left loin pain and dyspnoea with recent onset of haemoptysis. After extensive evaluation, she was referred to urology where she underwent a laparoscopic assisted open left radical nephrectomy which was reported to be Collecting duct carcinoma.This case is being presented for the diagnostic dilemma it elicited throughout the evaluation.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Conclusionsurgery with either anterior or posterior decompression should assure complete clearance of the lesion, correcting the kyphotic deformity that prevents disease progression.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In this study, we developed a novel immunotherapeutic peptide by linking the Mycobacterium tuberculosis (MTB) heat shock protein 70 (Hsp70) functional peptide to the extracellular domain of FPR1, a protein overexpressed in cervical cancer, to obtain an MTBHsp70-exFPR1 fusion protein. Our experiments confirmed that the MTBHsp70-exFPR1 protein could promote DC maturation and induce the secretion of IL-12p70, IL-1β, and TNF-α. The antitumor effect of human cytotoxic T lymphocytes (CTLs) activated by autologous DCs was assessed in NOG mice. These results indicate that DCs pulsed with MTBHsp70-exFPR1 can enhance anti...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
ConclusionsWe found that MSCs combined with hydroxyapatite represents a potential therapy for bone regeneration in VBD. Further clinical studies are required to investigate the safety and efficacy of this combination of therapy in VBDs.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Limited data exist on the development of tuberculosis (TB) in cancer patients receiving immune checkpoint inhibitors (ICIs).
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Short communication Source Type: research
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