The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome.

The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome. J Anat. 2019 Feb 21;: Authors: Gilbert-Jaramillo J, Garcez P, James W, Molnár Z, Clarke K Abstract The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (ER) stress, immunity and dysregulation of RNA and energy metabolism both in vivo and in vitro. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following ZIKV infection, contributing to developmental abnormalities. Brain energetic failure has been implicated in neurological conditions such as autism disorder and epilepsy, as well as in metabolic diseases with severe neurodevelopmental complications such as Glut-1 deficiency syndrome. Therefore, these energetic alterations are of wide-ranging interest as they might be directly implicated in congenital ZIKV syndrome. Data showing increased glycolysis during ZIKV infection, presumably required for viral replication, might support the idea that the virus can cause energetic stress in the developing brain cells. Consequences may include neuroinflammation, cell cycle dysregulation and cel...
Source: Journal of Anatomy - Category: Anatomy Authors: Tags: J Anat Source Type: research

Related Links:

Authors: Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR Abstract Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders primarily affecting the white matter of central nervous system. These conditions are often under-appreciated among physicians. The first clinical manifestations of leukodystrophies are often nonspecific and can occur in different ages from neonatal to late adulthood periods. The diagnosis is, therefore, challenging in most cases.Area covered: Herein, the authors discuss different aspects of leukodystrophies. The authors used...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
ConclusionThe Indonesian PATE scale is a validated and reliable translation for measuring public attitudes toward epilepsy.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 December 2019Source: Epilepsy &BehaviorAuthor(s): Gunilla Rejnö-Habte Selassie, Göran Pegenius, Tomas Karlsson, Gerd Viggedal, Tove Hallböök, Mikael ElamAbstractWe used a stepwise process to develop a new paradigm for preoperative cortical mapping of receptive language in children, using temporary functional blocking with transcranial magnetic stimulation (TMS). The method combines short sentences with a lexical decision task in which children are asked to point at a picture that fits a short sentence delivered aurally. This was first tested with 24 healthy chil...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, the therapeutic use of phytocannabinoids (CBD) is already in practice, although its mechanisms of action remain unclear. Endocannabinoid and TRPV1 mechanisms warrant further basic studies to support their potential clinical applications.This article is part of the Special Issue “NEWroscience 2018".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 12 December 2019Source: Brain StimulationAuthor(s): Uma V. Mahajan, Jonathon J. Parker, Nolan R. Williams, Mahendra T. Bhati, Seul Ku, Gerald Grant, Robert S. Fisher, Sherman C. Stein, Casey H. Halpern
Source: Brain Stimulation - Category: Neurology Source Type: research
Publication date: Available online 13 December 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Hollian R. Phillipps, Siew H. Yip, David R. GrattanAbstractProlactin is pleotropic in nature affecting multiple tissues throughout the body. As a consequence of the broad range of functions, regulation of anterior pituitary prolactin secretion is complex and atypical as compared to other pituitary hormones. Many studies have provided insight into the complex hypothalamic-pituitary networks controlling prolactin secretion patterns in different species using a range of techniques. Here, we review prolactin secretion in b...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
(CNN/CBS) — At least 1,300 people have died from the flu so far this season, according to a preliminary estimate released Friday by the US Centers for Disease Control and Prevention. There have been at least 2.6 million flu illnesses and 23,000 flu-related hospitalizations, according to the analysis. So far this season, the CDC has received reports of 10 children who have died from the flu, four more than the week before. Experts have warned that flu is hitting the United States early this year, and there are concerns that this early season could mean a particularly severe season overall. Flu spread significantly in ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Flu Source Type: news
The pediatrician kept on telling me that everything was fine. What could possibly be wrong? His motor skills were right on time, if not a little early.   He even had emerging problem-solving skills. He did things like push a chair up to a shelf to climb up and get what he wanted.  Three decades later, […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Patient Pediatrics Psychiatry Source Type: blogs
Authors: Qiu S, Wang F, Hu J, Yang Y, Li D, Tian W, Yuan X, Lv Y, Yu M Abstract Primary contents of dietary fat are three or four types of fatty acids, namely saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), n6-polyunsaturated fatty acid (n6PUFA) and, to less extent, n3-polyunsaturated fatty acid (n3PUFA). Previous studies suggest that increased SFA, MUFA, and n6PUFA in high fat diets (HFDs) stimulate the origination, growth, and liver metastasis of pancreatic cancer cells, whereas increased n3PUFA has the opposite effects. It is unclear whether the fatty acid-induced effects are based on changed fatt...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Source: Cell - Category: Cytology Source Type: research
More News: Anatomy | Autism | Brain | Carbohydrates | Diets | Epilepsy | Genetics | High Fat | Neurology | Nutrition | Perinatology & Neonatology | Pregnancy | Study | Zika Virus