The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome.

The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome. J Anat. 2019 Feb 21;: Authors: Gilbert-Jaramillo J, Garcez P, James W, Molnár Z, Clarke K Abstract The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (ER) stress, immunity and dysregulation of RNA and energy metabolism both in vivo and in vitro. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following ZIKV infection, contributing to developmental abnormalities. Brain energetic failure has been implicated in neurological conditions such as autism disorder and epilepsy, as well as in metabolic diseases with severe neurodevelopmental complications such as Glut-1 deficiency syndrome. Therefore, these energetic alterations are of wide-ranging interest as they might be directly implicated in congenital ZIKV syndrome. Data showing increased glycolysis during ZIKV infection, presumably required for viral replication, might support the idea that the virus can cause energetic stress in the developing brain cells. Consequences may include neuroinflammation, cell cycle dysregulation and cel...
Source: Journal of Anatomy - Category: Anatomy Authors: Tags: J Anat Source Type: research

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Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Flu Source Type: news
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Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Patient Pediatrics Psychiatry Source Type: blogs
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Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
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Source: Cell - Category: Cytology Source Type: research
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