Cell-penetrating peptides: from cell cultures to in vivo applications.

Cell-penetrating peptides: from cell cultures to in vivo applications. Front Biosci (Elite Ed). 2013;5:509-16 Authors: Regberg J, Eriksson JN, Langel U Abstract The field of gene therapy is starting to move towards clinical applications but is currently limited by the lack of efficient delivery systems. Cell-penetrating peptides provide a means of cellular delivery for gene therapy applications as well as delivery of traditional drugs. Using cell-penetrating peptides a range of different cargoes have been successfully delivered into a number of cell types, in vitro as well as in vivo. In this review we discuss uptake mechanisms of different cell-penetrating peptides, with or without cargo. The transition from in vitro to in vivo applications and strategies to increase the bioavailability of cell-penetrating peptides are also discussed. PMID: 23277006 [PubMed - indexed for MEDLINE]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research