Transcriptional Regulation of Nos2 via STAT5B Binding to Nos2 Gene Promoter Mediates Nitric Oxide Production: Relevance in β-Cell Maintenance.

CONCLUSION: Our study enables us to conclude that β-cell stress is aggravated by the incapability of STAT5B to induce Nos2 resulting in H₂O₂ accumulation and the ensuing oxidative stress enhances β-cell damage. PMID: 30790510 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30790510?dopt=Abstract

Source: Physiological Research - February 24, 2019 Category: Physiology Authors: Joseph A, Nair LCR, Johnson BS, Thomas PL, Padmanabhan RA, Puthumadathil N, Laloraya M Tags: Cell Physiol Biochem Source Type: research