Williams' neural stem cells: new model for insight into microRNA dysregulation.

Williams' neural stem cells: new model for insight into microRNA dysregulation. Front Biosci (Elite Ed). 2013;5:1057-73 Authors: Palacios-Reyes C, Espinosa A, Contreras A, Ordonez R, Hidalgo-Miranda A, Rubio-Gayosso I, Garcia-Alonso P, Benitez-King G, Ramirez-Rodriguez G, Najera N, Ita-Islas I, Araujo A, Romero-Cordoba S, Palma I Abstract Williams syndrome (WS) is a neurodevelopmental genetic disorder, due to a 7q11.23 hemizygous deletion. WS has a characteristic neurocognitive profile that includes intellectual disability (ID). Haploinsufficiency of some of the deleted genes is partially associated with the cognitive phenotype. The aim of this paper is to determine the differences in the microRNA (miRNA) expression in WS patients, using a neural cell model from the patients olfactory neuroepithelium (ONE), and to establish the relationship with those genes involved in neurodevelopment and neural function. To assess these goals, we made a comparative analysis of the miRNAs expression profile between WS patients and controls. Through an in silico analysis, we established potential pathways and targets associated with neural tissue. The expression profile shows 14 dysregulated miRNAs, including nervous system (NS)-rich miRNAs such as miR-125b, let-7c and miR-200. Most of these miRNAs have potential targets associated with NS functions while others have been reported to have specific neuronal functions. These data suggest that miRNAs wi...
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research