Involvement of PARPs in cell death.
Involvement of PARPs in cell death.
Front Biosci (Elite Ed). 2014;6:308-17
Authors: Aredia F, Scovassi AI
Abstract
Poly(ADP-ribosylation), an NAD dependent reaction culminating in the formation of ADP-ribose monomers, and their following polymerization, is activated as an emergency process in crucial situations such as DNA damage and cellular stress; due to this crucial function, the modulation of poly(ADP-ribosylation) during cell death has been investigated. This review will describe the properties of poly(ADP-ribose) as a signalling molecule in different paradigms of cell death, i.e.apoptosis, parthanatos, necroptosis and autophagy.
PMID: 24896207 [PubMed - indexed for MEDLINE]
Source: Frontiers in Bioscience - Elite - Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research
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