Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis - Evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis.

Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis - Evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2014;31(3):182-90 Authors: Mochizuki I, Kubo K, Hond T Abstract We have observed that electron microscopically there were many damages of the plasma membrane of the bronchial and lung capillary endothelial cells in sarcoidosis and at the same time, platelets adhesion and eosinophil attached to the capillary vessels. And characteristically, the capillary endothelial cells showed appearance of the lipid droplets including saturated and unsaturated fatty acids in the cytoplasm and capillary lumina in all cases. For elucidation of the functions in the capillary endothelial cells, we performed the histochemical study of monoclonal antibody for von Willebrand factor (vWf) antigen by the ABC method on the 22 bronchial and lung biopsied cases and 15 control subjects. The vWf showed a strong reaction in wide range with exsudation towards outside and occlusion or dilatation in the capillary walls and the area showing alveolitis disclosed also strong reactivity with exsudation. Dilated or occluded capillaries were observed and finally they disappeared in the tissue. These widespread capillary's hyperreactivity were observable in the remote area from granuloma, and the capillaries in the matured granulomas were found signif...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

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Authors: Rodriguez-Gonzalez M, Perez-Reviriego AA, Castellano-Martinez A, Cascales-Poyatos HM Abstract Kawasaki disease (KD) is a systemic childhood vasculitis with peculiar tropism for the heart. Coronary artery aneurysms are the primary cause of morbidity and mortality in these patients. The timely administration of gammaglobulin decreases the risk for development of coronary artery aneurysms, highlighting the importance of early KD recognition. However, the most significant dilemma in the management of KD is the diagnosis itself. In this article, we review the recent literature focusing on the diagnostic utility...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
We report the rare case of a 45-year-old female presenting with symptoms of intracranial hypertension and leukodystrophy-like neuroimaging findings. A comprehensive diagnostic work-up led to the unexpected diagnosis of a definite PACNS which was successfully treated by immunosuppressive treatment. Although rarely, PACNS can present as diffuse leukoencephalopathy on neuroimaging, and mimic even an inherited leukodystrophy. Therefore, in adults with leukodystrophy-like neuroimaging findings, careful examination of clinical and non-clinical features is mandatory to avoid missing the diagnosis of a treatable acquired disease.
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In this study, we investigated the role of LXA4 in inflammation-mediated cerebrovascular endothelial dysfunction and the potential mechanism after SAH. SAH was induced by endovascular perforation in male Sprague–Dawley rats, and recombinant LXA4 was injected intracerebroventricularly 1.5 h after the operation. The expression changes in the markers of endothelial dysfunction (endothelial microparticles and nitric oxide) were analyzed by flow cytometry or Nitric Oxide (NO) assay kit. Microflow in the cerebral cortex was assayed by laser speckle contrast imaging. Neutrophil infiltration was observed by a marker of leu...
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Although it is the general consensus that sarcoidosis patients who present with sarcoidosis-related symptoms have a worse outcome than patients whose disease is detected incidentally without symptoms, this premise has not been rigorously examined.
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