The Neuroprotective Effect of Histamine H4 Receptor Antagonist on Dopaminergic Neurons in Parkinson ’s Disease

AbstractThis research was aimed to explore the neuroprotective effects of histamine H3 and H4 receptor antagonists on dopaminergic (DA) neurons in Parkinson ’s disease (PD) model rats induced by 6-hydroxydopamine (6-OHDA) and their mechanism. The changes of the level of monoamine neurotransmitters, the number and morphology of TH-positive cells, and inflammatory factors in the striatum were used to evaluate the protective effects of H3 and H4 receptor antagonists on PD rats. The effects of histamine H4 receptor antagonist on the activation of microglial cell in PD rat and cells of PD model were observed, further exploring the mechanism of H4 receptor antagonist in improving the damage of PD rats. The results of open-field test and rotarod test s howed that histamine H4 receptor antagonist significantly improved rotarod time and autonomic activity in PD model rats (P <  0.05). In addition, H4 receptor antagonist also had a significant protective effect on inflammatory lesions in PD model rats induced by 6-OHDA (P <  0.05) and was able to significantly regulate level changes of monoamine neurotransmitter DA and DOPAC in the striatum (P <  0.05) and number and morphology of TH-positive cells, and inhibit activation of microglial cell. Cell experiment results showed that H4 receptor antagonist had no significant protective effect on cells of PD model. Histamine H4 receptor antagonist had a protective effect on dopamine neurons in th e substantia nigra of PD...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research