Collagen peptides administration in early enteral nutrition intervention attenuates burn-induced intestinal barrier disruption: Effects on tight junction structure

Publication date: April 2019Source: Journal of Functional Foods, Volume 55Author(s): Qianru Chen, Xiang Gao, Hongwei Zhang, Bafang Li, Guangli Yu, Bo LiAbstractThe effect of collagen peptides (CPs) administration in early basic enteral nutrition (EN) intervention after burn injury on intestinal barrier function was investigated in mice model. Burn-induced increases of intestinal permeability and disruption of intestinal barrier integrity were significantly attenuated by CPs supplemented EN at post-burn day 1, 3 and 7 as compared with only basic EN fed group. CPs revealed a prominent amelioration of the expression and localization of tight junction protein ZO-1 and occludin in intestinal mucosa. Furthermore, CPs administration significantly inhibited burn-induced elevation of MLCK expression and MLC phosphorylation. Simultaneously, the activation of involved signal pathways, such as NF-κB p65, MAPK p38, ERK and JNK were diminished in different extent by CPs addition. Therefore, CPs could be considered as a beneficial adjunct in early EN intervention to prevent intestinal barrier disruption following burn injury, because of its protective effects on intestinal tight junction integrity.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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