Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats.

CONCLUSIONS: NALFD can lead to a reduction in the hepatic CLint of a drug if it is a substrate of the CYP2D subfamily. The decreased clearance may result in elevated drug concentrations and increased exposure. PMID: 30786957 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30786957?dopt=Abstract

Source: J Pharm Pharm Sci - February 23, 2019 Category: Drugs & Pharmacology Authors: Bang WS, Hwang YR, Li Z, Lee I, Kang HE Tags: J Pharm Pharm Sci Source Type: research