03:27 PM Abstract No. 221 Porcine and human hepatocellular carcinoma cell lines present similar drug-metabolizing enzyme expression levels and comparable sorafenib and doxorubicin cytotoxic responses

The Oncopig Cancer Model (OCM) is a unique transgenic porcine model that develops inducible site and cell specific tumors, and permits in vitro pharmacologic screening using cell lines with the ability to translate promising strategies to in vivo using solid organ tumors. To validate OCM utility for in vitro drug screening, this study tested the hypothesis that OCM and human hepatocellular carcinoma (HCC) cell lines exhibit similar expression of drug-metabolizing enzymes (DMEs) and comparable dose response to standard chemotherapies.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 23: Nothing Basic About It (Basic Science Oncology) Source Type: research