04:12 PM Abstract No. 226 Glypican-3 optical molecular imaging enables in vivo detection and monitoring of response to adoptive immunotherapy

We have previously described synthesis of a bispecific fusion protein for catheter-directed targeting of glypican-3 (GPC3) expressed on hepatocellular carcinoma (HCC) tumors and CD3 T-cell receptors (GPC3-CD3-bsAb) (1). We hypothesized that in vivo optical fluorescent imaging of GPC3 in mouse models of human HCC would enable effective monitoring of adoptive immunotherapy mediated by GPC3-CD3-bsAb.

Source: Journal of Vascular and Interventional Radiology : JVIR - February 23, 2019 Category: Radiology Authors: P. Habibollahi, J. Hui, M. Mercadante, A. Tsourkas, G. Nadolski, S. Hunt, T. Gade Tags: Scientific Session 23: Nothing Basic About It (Basic Science Oncology) Source Type: research