03:45 PM Abstract No. 378 Establishment of hepatocellular carcinoma patient-derived xenografts from minimally invasive image-guided percutaneous biopsies

The generation of patient derived xenografts (PDXs) from core needle biopsies of intermediate and advanced stage  HCC patients who are not candidates for resection is technically challenging due to the small quantities of tumor tissue obtained. Further complicating PDX generation is the high rate of EBV infection in humans (>90%) and the presence of EBV-transformed B lymphocytes in HCC samples, which grow opportunistically in immunocompromised mice to  yield EBV-associated lymphomas at the expense of HCC xenografts.

Source: Journal of Vascular and Interventional Radiology : JVIR - February 23, 2019 Category: Radiology Authors: D. Tischfield, D. Ackerman, M. Noji, J. Chen, N. Perkons, G. Nadolski, S. Hunt, M. Soulen, E. Furth, T. Gade, D. Tischfield Tags: Scientific Session 39: Needle in a Haystack (Biopsies) Source Type: research