04:03 PM Abstract No. 390 Pharmacokinetic verification of loco-regional delivery of caffeic acid using drug-eluting beads in a large animal model

Caffeic acid (CA) is a natural phytochemical with lethal effects against hepatocellular carcinoma in vitro. However, efficacy requires high locoregional concentrations. Currently available porous hydrogel beads are derivatized with sulfonic acid groups and at neutral pH these negatively charged groups provide binding sites for the cationic drug doxorubicin. A loading protocol was developed for these drug-eluting beads to retain and release neutralized CA for embolic delivery. Pharmacokinetic analysis in an animal model compared loaded beads to an alternative embolic delivery method.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 40: The Lab Source Type: research