Increased androgen secretion in patients with prolactinomas: the impact of altered HPA function

AbstractBackground and objectivesEarlier studies suggested that hyperprolactinemia was associated with elevated serum DHEA-S levels. The importance of DHEA-S measurements in the diagnosis of adrenal insufficiency prompted us to assess adrenal androgen levels in hyperprolactinemic subjects with normal or impaired function.MethodsProspective study including 122 medically treated and 26 surgically patients with prolactinomas. Serum PRL, DHEA and DHEA-S levels were measured before and repeatedly after cabergoline therapy and also in the perioperative period of surgically treated patients.ResultsSerum PRL levels decreased (P  
Source: Pituitary - Category: Endocrinology Source Type: research

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Publication date: Available online 9 July 2019Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Oliver McCallion, Krithi Ravi, Darren Fowler, Shaun Wilson, Kokila LakhooAbstractA previously well fifteen-month-old female infant presented to a district general hospital in the United Kingdom with a three-month history of virilisation developing facial acne, coarse pubic hair, labia majora hypertrophy, menstruation, and clitoral enlargement. A functional adrenal tumour was suspected, supported by raised androgen metabolites on urinary steroid profile. An abdominal ultrasound scan identified a unilateral left adrenal ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
;cs A Abstract NR0B1 (nuclear receptor subfamily 0, group B, member 1) is a transcription factor encoded by DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) responsible for the development and maintenance of the steroidogenic tissues. In humans the DAX1 mutations cause congenital adrenal hypoplasia (AHC) and hypogonadotropic hypogonadism (HHG) in boys. Here we report two brothers who were assessed by endocrinologist at the age of 51 and 43 because of their serious osteoporosis. They had been substituted with prednisolone since the age of 4 and 9 years because o...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
The use of adrenalectomy in treatment of primary aldosterone can lead to persistent adrenal insufficiency, so postoperative adrenocorticotropic hormone stimulation testing is recommended to avoid adrenal crisis, according to German research published inThe Journal of Clinical Endocrinology& Metabolism.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
This article is protected by copyright. All rights reserved. PMID: 31269232 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Authors: Arima H, Iwama S, Inaba H, Ariyasu H, Makita N, Otsuki M, Kageyama K, Imagawa A, Akamizu T Abstract Immune checkpoint inhibitors (ICIs) have become a promising treatment for advanced malignancies. However, these drugs can induce immune-related adverse events (irAEs) in several organs, including skin, gastrointestinal tract, liver, muscle, nerve, and endocrine organs. Endocrine irAEs comprise hypopituitarism, primary adrenal insufficiency, thyroid dysfunction, hypoparathyroidism, and type 1 diabetes mellitus. These conditions have the potential to lead to life-threatening consequences, such as adrenal crisi...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Conclusion: The HIV drug efavirenz inhibits CYP21A2 activity in vitro through direct interaction with enzyme catalysis at therapeutic concentrations. This may have clinical implications for HIV treatment in children and adults. However, so far, clinical data are scarce, and further studies are needed to be able to draw clinical conclusions.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Geetanjali T Chilkoti, Anshul Singh, Medha Mohta, Ashok Kumar SaxenaJournal of Anaesthesiology Clinical Pharmacology 2019 35(2):147-152 Various exogenous steroid preparations have been in use for a wide range of indications. We, as an anesthesiologist often encounters a surgical patient receiving chronic steroid therapy. Perioperative use of steroid is associated with major complications such as full-blown adrenal crisis in the perioperative period due to the secondary adrenal insufficiency. Henceforth, comes the role of the perioperative “stress-dose” of steroids to mitigate this rare but potentially fatal co...
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
Authors: Sekizaki T, Kameda H, Oba C, Yong Cho K, Nakamura A, Miyoshi H, Osawa T, Shinohara N, Atsumi T Abstract A 62-year-old man was referred to our department for elevation of plasma ACTH and cortisol levels during nivolumab administration for renal cell carcinoma. Although his ACTH and cortisol levels had been maintained within their reference ranges, they were elevated to 232.7 pg/mL and 21.9 μg/dL, respectively, after eight courses of nivolumab without any subjective symptoms or Cushing's sign. He was hospitalized for endocrinological investigation. ACTH and cortisol returned to their normal ranges (29.18 ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Nivolumab, an anti-programmed cell death-1 monoclonal antibody, is currently used to treat many types of advanced cancers including recurrent and metastatic head and neck cancer. However, there are increasing reports concerning immune-related adverse events related to nivolumab therapy. Here, we report three patients who presented with adrenal insufficiency following nivolumab therapy. Two were diagnosed as having isolated adrenocorticotropic hormone (ACTH) deficiency and one was diagnosed as having primary adrenal insufficiency.
Source: Auris, Nasus, Larynx - Category: ENT & OMF Authors: Source Type: research
Cortisol is a glucocorticoid hormone secreted by the adrenal in a circadian manner in response to adrenocorticotropic hormone (ACTH) released from the pituitary, which is turn is stimulated by corticotropin releasing hormone from the pituitary. Cortisol has a critical role in homeostasis. Cortisol deficiency may present with nonspecific symptoms of lethargy, headache, nausea, abdominal pain, symptoms of hypoglycaemia and failure to thrive or weight loss. Patients with primary adrenal insufficiency may be pigmented due to an increase in melanocyte stimulating hormone, a cleavage product POMC, the precursor of ACTH.
Source: Paediatrics and Child Health - Category: Pediatrics Authors: Tags: Symposium: endocrinology Source Type: research
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